D

diyCTB

Mage
Oct 28, 2018
511
Hi,

Is Alprazolam good substitute for benzodiazepines?

I also checked drug interactions and saw that there is a serious interaction between Tagamet and Alprazolam but they don't explain what kind of interaction.

Screenshot 20201128 215423 Chrome
 
Gnip

Gnip

Bill the Cat
Oct 10, 2020
623
Alprazolam is a benzodiazepine.

Alprazolam is the chemical name, the trademark name is Xanax.

I have prescriptions for both alprazolam and clonazepam. Alprazolam is quick acting, so fast in fact that my father takes it while driving long distances when vertiginous lines of convergence from a road or bridge in front of him triggers a panic attack while he's behind the wheel. (He inherited this from his mother, but unfortunately in her day, benzodiazepines were not available to counteract her panic attacks.) My father keeps some alprazolam tablets in an Altoids box magnetized to his dashboard with a bottle of water in the center console at his ready if he's abruptly seized by a neurological anxiety fit in the middle of driving across a high, long and narrow bridge, or straightaway stretching into the distance. (He does not suffer these panic attacks at night, when those vertiginous lines of convergence are not visible, but his eyesight at night no longer allows him to drive such distances after darkness falls.) Alprazolam leaves the system in about four hours.

Four hours is how long it takes Klonopin (clonazepam) to reach peak effect, and it takes about 40 hours to leave the system. In cases where clinical anxiety is preventing sleep, alprazolam can ease anxiety quickly, while clonazepam can ease anxiety for extended periods.

The common sleep medication Restoril (temazepam) is also a benzodiazepine, a hypno-narcotic and respiratory suppressant which was my go-to sleep medication for decades until tachyphylaxis kicked in. Good stuff, but you need a psychiatrist or sleep medicine specialist to get a reliable and adequate supply.


A fine introductory book to read about benzodiazepines and the medical management of clinical anxiety is 1986's "The Anxiety Disease" by David V. Sheehan, MD, an old friend and associate of my psychiatrist. Sheehan's all about the medicine and biochemistry of anxiety.
 
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RubberMan

RubberMan

Pharmacology/Toxicology Nerd
Oct 10, 2020
14
Hi,

Is Alprazolam good substitute for benzodiazepines?

I also checked drug interactions and saw that there is a serious interaction between Tagamet and Alprazolam but they don't explain what kind of interaction.

View attachment 52851
The interaction is mediated by the hepatic enzyme CYP450 3A4. Cimetidine is a moderate inhibitor of multiple CYP's, so it should result in less first-pass metabolism of Alprazolam. If anything this is desirable for the effects most people are looking to get from benzo's on this forum as it will result in higher systemic concentrations of Alprazolam, thereby making each mg of the compound more sedating and may even get into the realm of respiratory depression if you combine them in high enough quantities. If you REALLY want to get the most out of this though, use grapefruit juice as well. The combination of Cimetidine and grapefruit juice should result in a near-complete blockade of Alprazolam metabolism, meaning the nearly full dose of each tablet should be present in serum (effectively getting you more drug per pill). Hell, you might even be able to get near IV-administration levels of Alprazolam that way.
 
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diyCTB

Mage
Oct 28, 2018
511
I want to take Alprazolam after drinking SN since it is quick acting.
 
D

diyCTB

Mage
Oct 28, 2018
511
@I screwed up I have Alprazolam pack but it expired in 2018. Do you think taking twice the dose will compensate for some loss in its potency?
 
L

Lizzy199075

Member
Feb 20, 2019
30
Food for thought...promethazine is now being more recognised as to help with calming/ agitation and sleep as an individual is able to have it several times a day. It is also available over the counter. I prefer using promethazine than a benzo mainly just because of the addictiveness of benzo's from having used both in the past for me personally promethazine had a better effect for settling my thoughts and presentation as well as getting to sleep. I recognise that this may not be the case for all but worth a try with approval from a health professional.
 
I

I screwed up

Waiting for the damn bus
Sep 11, 2019
884
@I screwed up I have Alprazolam pack but it expired in 2018. Do you think taking twice the dose will compensate for some loss in its potency?
Sorry bro .. Not sure abt that .. True the potency will reduce but taking twice the dose , am not sure .. May be someone els on the site may be well Informed