Well...it's a complicated answer to a complicated question. Certainty of something like this requires future sight, which no one has, honestly. I'm pretty sure humans were once "certain" that going into space was not possible, that the earth was round/the back of a giant turtle/etc. At this point we can have a pretty good idea of things a reasonable distance into the future, but the nature of existence is fluid - today's inconceivable is tomorrow's impossible is the next day's improbable, and so on. With that out of the way...
What's meant by "you"? The body, the mind, something else? If the body, I've already been told by two surgeons they wouldn't advise surgery for two of the three main issues I have in the same area. In addition to/other than that, this flesh container will just continue degrade as time goes on.
If not the body, my "problem" is that unless you use the cop-out explanation of "outlook", I don't think it's me that needs fixing. I've just had it with the apparent fact that the default condition of all sentient life is either dissatisfaction or outright misery, and that to live is to constantly struggle against this. You might get to a place where, if you're lucky, you both are always content and forget or don't care that everything could be pulled out from under you in an instant, but once you've been as low as many of us have, I'm not sure that's a possibility. I think most who've come face-to-face with the abyss carry a mark of that encounter for the rest of their lives, and for most of those simply moving about the world is a changed phenomenon.
My pool of mana has been slowly depleting for a long time, with less and less refilling it, and the rate of emptying increasing exponentially. Eventually there won't be enough to sustain this existence anymore.