How important are antacids for SN exactly?

[Mrikaii]

For personal reasons I can't get an antacid for the SN method, however I have everything else (meto, ibuprofen and the SN itself), stan's guide says that the antacid's purpose is to transfer more SN to the small intestine, in that case should I be ok if i don't use an antacid and just increase the SN dose a little?

 

[Sherri]

I dunno exactly maybe for you not to throw up, but I know many cases where people just used sn alone. Depends I guess.

 

[Versailles]

The PPH recommends decreasing the volume of fluid in your stomach so that sodium nitrite is absorbed more quickly. This can be done with medications that reduce stomach acid quickly.
In the PPH it says: "Some reports erroneously state that acid reduction is counterproductive as it reduces NO release, hypotension, and headache."

 

[LostAllHope88]

I can't remember where I found it on here, but this is what I found in an SN guide:

The purpose of antacid has nothing to do with quicker absorption of SN. In your stomach there is something called gastric juices, one of the components of this juice is hydrochloric acid (HCL). When SN mixes with HCL, it converts to regular salt (NaCL). There isn't enough HCL in your stomach to convert all the recommended dose, but it will reduce it. Therefore less SN gets passed to the small intestine where the process of actually transferring it into bloodstream starts. The stomach only prepares the food for digestion, it does not absorb it into the bloodstream. So the purpose of antacid is to help reduce that conversion so more SN moves into the small intestine. You may see that there are conversations regarding complex medications to reduce the amount of stomach acid. It is not necessary. Regular stores and pharmacies will sell easy to obtain medications that cure indigestion and excess stomach acid. After research, it was found that proton pump inhibitors (PPI) were not useful for the SN process. Nor any other drug that changes the behaviour of your stomach producing acid. You only need something that reduces the stomach acid quickly. Excess normal salt (NaCl) in your stomach may also produce some stomach discomfort which makes it a good thing to take them.

 

[DyingMiND]

I guess it the reagents sodium nitrite and HCl were in equilibrium with the products of NaCk, NO and nitrate, a change in the concentration of the HCl would definitely change there amount of product. So, if HCl production, or the active H+ ion, concentration decreasedn( ie. There would be a less acidic environment (increased pH) and the equation would be driven to the left, favoring sodium nitrite to remain but less amount of salt, NO and nitrate. But, this is if there is a steady state equilibrium. I do not know of other specific details such as heat production or not.

When thinking about Stan's guide when it states that there isn't enough stomach acid (HCl) to mix with SN, then more SN remains basically unchanged (unable to interact with HCl) and delivered to the small intestine. This seems to make sense overall. However, if looked HCl reacts to SN in the stomach, then it seems logical that there will be less salt, NO and nitrate production.

I am not a chemist nor an expert in this area and can only make comments of what I know. What I do know is that the " behavior" of the gut is changed by using histamine blockers (cimetedine, ranitidine, etc and by PPI. They both at on parietal cells of the stomach to reduce hydrogen ion production. Antacids, such as calcium carbonate, only "soak up" some stomach acid and reduce acidity to a minimal extent and not as defective as the other 2 types. PPIs are more effective than histamine blockers, but take more days to become effective.

So, I don't know if I should take a PPI or stick with the HE blockers. I am wondering if a beta blocker would be helpful in the overall process as a potentiator???. PPH recommend it but I'm not sure at this point. I'll try and search through some more threads.

Does anybody have any suggestions? I know the decision is mine in the end but any theories about even using an acid regulator or not? I know some people on this forum have mentioned that they won't but I forget exactly their reasoning