High dose Antiemetic for SN protocol?

[braketimez]

This study shows that high dose Metoclopramide (100 mg) prevented vomitting in 53% of chemo patients: https://www.ncbi.nlm.nih.gov/pubmed/4050745

Other than the potential (only potential...not inevitable) side effects of restlessness and dystonia, would there be any reason to not try a dose of this amount for the SN protocol?

 

[jgm63]

Some extracts from here :
https://sanctioned-suicide.net/threads/n-protocol-regime-regimen-notes.27092/post-491007

The "old" meto doses were 60mg for stat, and 2 x 10mg at each interval for the 48 hour regime. These got revised to the "new" doses of 30mg for stat, and 1 x 10mg for the intervals.​

Derek Humphry - Final Exit author - suggests another alternative method of 1 x 10mg meto every hour, for 6 to 10 hours prior to taking the N, so you could go with that if it seems to better fit your situation ​

( that thread relates to N, but the antiemetic protocol is the same as for SN )

General notes on EPS and "meto testing" can be found here :
https://sanctioned-suicide.net/threads/n-protocol-regime-regimen-notes.27092/post-642667

 

[Quarky00]

This study is "dubious" . It does not provide data (in its current form) and is not reproduced by other studies.

Followed by oral metoclopramide at 1, 3, 5, and 8 hours after chemotherapy. Three oral dose levels were evaluated. Treatment with 2 mg/kg/dose or 100 mg/dose

It's unclear: 100mg per dosage , at 4 different times interval, is 400mg? Obviously not. So:

Do not take these published numbers as they are.

Adding more information, from recent N account:

Member that had taken > 100mg meto went to hospital due to severe side effects .

 

[braketimez]

This study is "dubious" . It does not provide data (in its current form) and is not reproduced by other studies.


It's unclear: 100mg per dosage , at 4 different times interval, is 400mg? Obviously not. So:

Do not take these published numbers as they are.

Adding more information, from recent N account:

Member that had taken > 100mg meto went to hospital due to severe side effects .

Thanks for this data, Quarky. Answers my question.

 

[one4all]

@Quarky00 you seem to have a sudden liking for the word "Dubious".

 

[jgm63]

This study is "dubious" . It does not provide data (in its current form) and is not reproduced by other studies.


It's unclear: 100mg per dosage , at 4 different times interval, is 400mg? Obviously not. So:

Do not take these published numbers as they are.

Adding more information, from recent N account:

Member that had taken > 100mg meto went to hospital due to severe side effects .

ok, but note that the old PPH recommendation used to be a stat dose of 60mg of meto.

If you did some testing, gradually increasing your amounts to determine if you are experiencing EPS, then you could build up to that dose....

I'm not making any suggestion regarding whether this is a good idea or not.

There is also this post :
https://sanctioned-suicide.net/thre...blockers-painkillers-draft.29822/#post-544562
where the recommended anti emetic seems to be 20mg meto plus ondansetron/zofran 8 to 24mg

 

[Quarky00]

I'm not making any suggestion regarding whether this is a good idea or not.

Lol so don't write "increase tolerance to take 60mg" Are you forgetting where we are and who's around us? Warnings are meaningless here. Expect soon "a mouthful of meto" ;)
(Just having a laugh)

 

[jgm63]

Lol so don't write "increase tolerance to take 60mg" Are you forgetting where we are and who's around us? Warnings are meaningless here. Expect soon "a mouthful of meto" ;)
(Just having a laugh)

Yes.....

On a serious note....
As I'm sure you'll agree, people are entitled to have information, and research and consider their options if they wish.

e.g. there might have been some merit to the old 60mg dose, but perhaps people didn't pay due diligence in testing and building up to it, so the recommendation was changed to 30mg. I'm not saying that's the case, I'm just saying it's a possibility that could warrant further investigation for individuals who are willing to put in the research effort.

We don't want to discourage people doing research, since that's how more nuanced information is obtained.

e.g. The OP could try contacting exit international to try to find out why the stat dose was changed from 60mg to 30mg, etc...