heroin:
>Duration(of action) Total:
>3 - 5 hours
>(The onset of effects is usually rapid and lasts for a few hours. [3])
>Subcutaneous LDLO (mouse): 262 Oral
>TDLO (mouse): 5 mg/kg; Subcutaneous TDLO (rat): 0.25 mg/kg;
>What Does Lethal Dose Low (LDLO) Mean? The lethal dose low is the lowest dosage of a compound that is introduced to the human body or that of an animal by any means apart from inhalation that will cause the death of the individual
mg/kg
>Toxicity LD 50 = 461 mg/kg (rat, oral), 600 mg/kg (mouse, oral).
it's ld50, it's average dose that causes death in 50% of sampling animals, not mistake it with LDLO as it's minimal dose that caused death in sampling animals
>Due to the nature of the unregulated drug market, illicit heroin is of widely varying and unpredictable purity. A user may prepare what they consider to be a moderate dose while actually taking far more than intended in the event of obtaining a purer product than they are used to, or may be cut unknowingly with more potent and dangerous substances such as fentanyl.[15] Depending on drug interactions and numerous other factors, death from overdose can take anywhere from several minutes to several hours and is a direct result of respiratory depression leading onto anoxia (oxygen deprivation) resulting from the breathing reflex being suppressed by agonism of µ-opioid receptors. Some sources quote the median lethal dose (for an average 75 kg opiate-naive individual) as being between 75 and 600mg.[16]
several grams can work given if: 1)it's adulterated with fent in considerable amounts as example 5mg per every 100mg 2)purity of heroin is at least 10% percent. on the other hand due to individual reactions on drugs it can be not enough, so you can end up braindamaged
methadone:
duration of action:
>It begins to take effect in about 30 minutes. The half-life of methadone (the time for blood levels to drop to 50 per cent of the peak concentration) is about 12 to 18 hours
>The duration of analgesic action of Methadone is 4 to 8 hours (based on single-dose studies) but the plasma elimination half-life is 8 to 59 hours. • With repeated dosing, the potency of Methadone increases due to systemic accumulation.
this is why re-dosing on methadone is approved only after passed day or so, if you introduce another dose before effect of previous didn't wore off you likely to OD on
>LD50 (rat, oral) = 30 mg/kg. Oral LD50 (mouse): 124 mg/kg .
methadone more toxic than heroin in 6-14 times per os
try to find methadone on the DM market instead, it should be more reliable, at least i heard it's diluted to a lesser degree
