Some notes on 48 hour vs stat :
The 48 hour regime might have a lower EPS risk since you're not taking so much antiemetic at once.
Some people suggest there's a lower vomiting risk with the 48 hour regime, but I haven't seen evidence to convincingly support that
There could be additional benefits to the 48 hour regime, other than the lower EPS risk, however it is not clear what those are (if any), although speculations have been made. If you have strong factual information on this then please share.
So based on your notes, the only benefit of the 2 day or 48 hr regimen over stat dose is lower EPS risk, besides mental preparation that some people need. There shouldn't be a significantly lower vomiting risk with the 48 hr regimen based on the pharmacokinetics of meto, which is in line with what you wrote.
half-life and clearance are dose-dependent , effects accumulate , and tolerance built (may ease side effects) . Increased rest tone of GI muscles / sphincters helpful . If it takes 48h-72h to eliminate , surely it accumulates . Meto can also be very harsh for certain people , with a single big dose
If 85% of orally administered meto appears in the urine within 72 hrs, sure the other 15% still remains in the body and there's accumulation to a small degree. Good point on a big single dose may be harsh for certain people, which leads to the question "why does it have to be meto as the AE of choice?"
I don't see what makes meto THE antiemetic choice. Stan listed a bunch of AEs and the PPH listed a bunch of AEs that can also work with the SN method, though both Stan and PPH used meto in their step by step guides. Many people talk about meto as if it's the only AE choice. I did find research articles that suggest meto speeds up the absorption of certain chemicals in the duodenum, which could potentially speed up SN death - the question is by how much.
There had been a discussion of meto (Reglan) vs Ondansetron (Zofran) on this forum before. It's pretty useful. If I can't decide a winner, seems like a good idea to take both.
https://sanctioned-suicide.net/threads/anti-emetics-reglan-vs-zofran.14609/
Regarding fasting, this section is copied and pasted from Stan's SN guide: "
Fasting is strongly recommended. Some people have medical conditions that mean fasting has a negative effect on them. Sources say that 8 hours is needed. I would suggest individuals know their own metabolism better than a book. If you know that your stomach feels empty after 4 hours, then I suggest you have a 4 hour fast. Try to avoid eating anything large and heavy. Avoid drinking anything two hours prior to drinking the SN." I would suggest the same as Stan suggested - fast as long as it's needed for your stomach to empty, but perhaps not much longer than that.
The night he wrote his goodbye post, he didn't eat. When I asked why, he said he wasn't feeling well.
He was probably fasting and didn't tell me. He fasted at least 5 hours.
Not feeling well how? Physically or emotionally?
Stan did the stat dose, right?
It must have been extremely difficult on you given how close you were to him. I'm so sorry for your loss.