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flakeyknight

Member
Jan 1, 2021
57
Just took a test dosage last night and had to urinate 4 times in an hour. After waking up I've had a consistent urge to twich. I dont get involuntary twitches but it doesn't feel comfortable if im not fidgeting and feel anxious throughout the day. I have to make my arm/leg tremor to feel comfortable. Sitting can get unbearable and I always get an urge to walk to feel at peace.

I checked my domperidone and I actually took 5 doses in 2021 when I bought it. Thought I had taken 2 doses before I put off my CTB date. Don't remember feeling bad at all from it. I took one last night but it was 7 months past its expiration so idk if that had anything to do with it. took it with the idea of sleeping through the side effects instead of taking it through the day where it could affect me in public but did not get a goods night sleep with a constant dry mouth and urge to urinate. I am trying to take dom for at least 2 weeks to get used to it and have maximum effect before I take SN. but day 1 of taking it again after 2 years off didn't feel so great. Has anyone else had this experience?
 
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Klimpop

Member
Jun 6, 2023
91
Just took a test dosage last night and had to urinate 4 times in an hour. After waking up I've had a consistent urge to twich.
Which domperidone brand did you take? How many mg did you ingest?
 
Last edited:
penguinl0v3s

penguinl0v3s

Wait for Me 💙
Nov 1, 2023
967
This is common in all dopamine antagonists, metoclopramide (Reglan) is even worse with the side effects. It's a really common side effect. In fact, dopamine agonists--opposite of antagonists--are a treatment for restless leg syndrome. They're both categorized as cholinomimetics because they're ACh release promoters, which basically are parasympathetic nervous system simulators.

 
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Klimpop

Member
Jun 6, 2023
91
How long would you say it took you to start noticing those side effects of restlessness, dry mouth and anxiety? Are you better now or are those side effects still lingering? I haven't tested my domperidone yet but I m thinking I will start with a dose of 5 mg or even less taken with a meal.
I m pretty sure I read a thread a while ago on meto side effects and it was suggested to take benadryl (diphnenydramine) to alleviate them.
 
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anonymous2025

anonymous2025

Still preparing to 🚍. 🌈
Apr 9, 2025
371
This is common in all dopamine antagonists, metoclopramide (Reglan) is even worse with the side effects. It's a really common side effect. In fact, dopamine agonists--opposite of antagonists--are a treatment for restless leg syndrome. They're both categorized as cholinomimetics because they're ACh release promoters, which basically are parasympathetic nervous system simulators.

Regan made me rip out my IV twice and I must have walked 5 miles the 2nd time. Taken with Benadryl and I'm fine.
 

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