A .410 caliber shotgun, although smaller and less powerful than larger gauges like 12 or 20, can still be extremely lethal, especially at close range. A slug fired from a .410 delivers a kinetic energy of approximately 675-810 joules, sufficient to penetrate the skull and reach the brain, even with a smaller caliber. The reduced diameter of the .410 concentrates the energy over a smaller surface area, increasing the pressure on impact, making it more likely to penetrate dense bones like the skull. At close range, a slug or buckshot travels at a speed of 365 to 550 meters per second; at these speeds, the shot causes massive tissue destruction, cavitation, and devastating damage if it hits vital areas such as the brain. A direct shot to the head can cause immediate and catastrophic damage, including hemorrhaging, brain swelling, and destruction of critical structures such as the brainstem. Even if the brainstem is not directly hit, the extent of the trauma makes survival extremely unlikely. At close range (0-5 meters), lethality is estimated to be around 90-100%, depending on accuracy and the type of ammunition used (slug or buckshot). Without medical intervention, if the shot is not immediately fatal, the chances of survival drop to almost zero due to massive bleeding, hypovolemic shock, or suffocation. While less powerful than larger calibers, a .410 shotgun is lethal at close range, especially if the head is the target, with the damage amplified by the concentrated force and sufficient energy to cause irreparable brain injuries or rapid death.