Why does the 2025 PPEH not mention taking anti emetics before day of CTB

[Luther84]

I noticed on many SN threads like vizzys that there is a 2 day regimen of taking meto. But the 2025 PPEH only mentions it taking the day off.

What's the best way to go about this?

 

[Forveleth]

It is not necessary to take antiemetics the day before. The PPH gives the minimum working protocol and therefore recommends them taken only in their effective time range. The half-life of most antiemetics is a few hours which means they will be excreted way before taking SN if they are started the day before. Vizzy mentions taking them early in his thread as a form of mental preparation but not as a necessity.

I think many people here start taking antiemetics early because many are afraid of vomiting with SN so they take extra even though there is no evidence it helps.