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fleshpuppet

fleshpuppet

Member
Jan 18, 2026
19
Was thinking of trialling bupropion and sertraline or fluoxetine and seeing if there's any improvement in my mood and motivation, but I've heard the side effects can be detrimental and I want to hear some opinions before I make the financial commitment. The main thing I'm concerned about is worse energy and undesirable mood changes. I'd also prefer if my dick worked but It's not like I really use it anyway so it's manageable. For people who take/have taken antidepressants, did it noticeably improve your mood? How were the side effects?

I'd be ordering the drugs off Indiamart because I don't want to go to a psychiatrist and have my parents aware of my affliction. Not sure how strict border control is in Australia, so hopefully it wouldn't get seized.

If you've had positive experiences with other substances, also open to other suggestions.
 
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hmu

hmu

New Member
Feb 7, 2026
1
I take desipramine every night and I've been on it for around 2-3 months. In my experience it gives me a very small short term relief but it's almost better to just not take it tbh. I am generally a weaker and lower energy person anyway so the side effects fuck me up even more and I get so tired I can't even stand properly. You also can't withdraw from it immediately so id only recommend it if you don't have multiple health problems or something that would interfere with it. That's just my experience don't rely on it too much
 
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orpheus_

orpheus_

Student
Apr 26, 2024
178
I'm on fluoxetine and bupropion, and described my experiences in other similar threads already:
For me they [meds] made things a lot better, actually gave me hope that life can be worth it in *any* way. I was lucky, honestly. The first medication I got (Fluoxetine) worked for me, while sometimes people need to go test a few meds before they get anything that works. I started feeling pleasure and joy from time to time after a long time of not being to experience it at all and generally I became less suicidal, and just.. existing hurt less. Also got more energy, while before I would sleep all the time. I had no unpleasant side effects (luckily for me, no emotional numbing which SSRIs CAN cause in some cases, I actually started feeling anything other than despair again) besides total apetite loss at the beginning which was not a big issue anyway. Oh and also very vivid dreams, which weren't really unpleasant, just weird? Apparently many people get them on SSRIs??
I've been on Fluoxetine for around 1,5 year, got added Bupropion 8 months ago. It gave me more "physical" energy and drive. I'm just more often motivated to do anything. I think it made me more irritable, though, but it's not like, extreme. It's just on fluoxetine only I was the most chill guy on earth and now sometimes things annoy me but not to the point where I can't control it or anything. Honestly it's also hard to tell for me what was exactly caused by meds, and what was caused by my very unstable life situation during the last year, so it's all a bit generalized.

I still feel like shit a lot of the time but at least I get some good moments and have energy to maintain (mostly) normal functioning. I'd say it was worth it from the recovery viewpoint. Honestly I did not put much hope in meds and I was quite surprised how much that actually changed for me. I'd say it's worth trying. I have only tried two medications because for a very long time I didn't want to, and now once I got something that's working *at all* I'm afraid of switching it to something potentially better (although I was offered switching it a few times and maybe that could help), I'm just too fucking scared I will go back to not functioning at all.

The risks of taking a medication or severity of discontinuation always vary by substance. I always keep repeating that: RESEARCH the med you are prescribed before taking it. Know the most common side effects as well as its benefits, know how long it will likely take to work. That can help you determine whether the benefits outweigh the risks. Most basic antidepressants like SSRIs are low-risk though. But be more careful with antipsychotics (they are often prescribed off-label for different conditions than psychosis, and while they can help a lot, they can cause worse side effects and you need to asses the risk) and benzodiazepines (they are physically addictive, your body builds tolerance to them quickly and, while they can work great for panic attacks since they calm you down quickly, after a few hours the effect wears off and you feel worse than without them).

I have been on fluoxetine (very commonly prescribed SSRI) for around 1,5 year. It got me out of an absolute shithole, honestly, it gave me access to feeling pleasure sometimes (which I lost for a long time). Also generally I feel less of that existential pain while on it, got more energy and less urges to self harm and less suicidal ideation. These problems did not disappear completely (especially as in the recent months I experienced some very messed up life events), but I still feel better taking it than not. I also got added Bupropion around 8 months ago, it gave me more energy and motivation, functioning is easier. Meds are definitely not enough, but they helped me a lot certainly. I only tried two because I'm really scared something will go wrong if I switch to something else, even potentially something more helpful. I got no side effects besides loss of apetite at the beginning of taking Fluoxetine and, I think, more irritability from Bupropion? Not sure if it's really because of the medication or something else, but I heard it happens to some people. For context I'm only diagnosed with depression (+ semi-official suspicions of ocd and adhd), the kind that's mostly low-energy and apathetic. Also did not like the idea of being drugged at first, but I got used to it.

I'd say giving it a try is worth it. However people react differently even to the same substance - still, there are some common patterns (for example Bupropion generally is mostly energizing rather than calming). Meds should ideally be matched to one's specific symptoms as closely as possible, still it's often a hit or miss. It's good to research the most common effects (both positive and negative) of a specific medication before you start taking it so you know what you're getting yourself into, also mind that some substances require a few weeks to work.
tldr, I had good experiences, meds didn't cure me but improved some things. Got very little side effects. Some of it was luck, some - just the fact that people who prescribed me these were *actually* thinking a bit...

Please be careful if you're going to work with meds without doctor's guidance, still I think they can make things better for you but it's very individual. Start with small doses and only one med first, then eventually add the second one. If your problem is lack of energy, fluoxetine and bupropion might help since they are activating. Fluoxetine usually does not cause sedation, but still it happens; Bupropion pretty much never does it from what I know. With seratraline, risk of energy drop is higher. Also all lof them carry some risks of influencing mood in a negative way especially at the beginning, but it varies. Like I said I did not experience them besides Bupropion on higher dose (300 mg) making me more irritable, still it's not bad and idk if it's actually the med or just me being less emotionally numb/life events causing me to loose my shit lol. With fluoxetine, my mood did not get worse than before meds at any point. Also for sexual dysfunction, it's generally very common with ssris (including fluoxetine and seratraline). Bupropion never causes it, though
 
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l1ablemistakes

l1ablemistakes

Wasted potential
Feb 16, 2026
204
I've been on 6 different mental health meds so I feel qualified to respond lol. (Fluoxetine, sertraline, quetiapine, citalopram, atomoxetine, venlafaxine)

Firstly, getting them from a GP is quite easy, you might not need to see a psychiatrist and even if you're under 18 they aren't necessarily obligated to tell your parents. Idk how hard it is to get drugs into Australia (I'm also Aussie) so I'd say try your luck with a doctor, it's probably safer and easier.

As for the meds I've been on, none of them have helped me significantly in the long term. That being said I'm not anti medication and I know several people it has helped. Fluoxetine didn't help but also had no side effects. It basically did nothing. Tastes like shit though.
Sertraline is a different story. When I started it, it caused a manic episode, which I've never experienced before. I nearly jumped a fence onto a highway lol. Also nearly jumped off the roof of a shopping centre. Said some questionable things to people. So start low and go slow.

The worst side effect for me is the withdrawals. They're pretty bad with sertraline and venlafaxine (my current medication). Brain zaps are horrible.

I never had any sexual dysfunction that I could ascribe to the meds. But that being said my depression affects my sex drive anyway. My partner is on a high dose of sertraline and has been for years, and he hasn't had that side effect either. I feel like maybe it's not as common as it seems?

Happy to answer any other questions! And I hope meds work out for you <3
 
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fleshpuppet

fleshpuppet

Member
Jan 18, 2026
19
I've been on 6 different mental health meds so I feel qualified to respond lol. (Fluoxetine, sertraline, quetiapine, citalopram, atomoxetine, venlafaxine)

Firstly, getting them from a GP is quite easy, you might not need to see a psychiatrist and even if you're under 18 they aren't necessarily obligated to tell your parents. Idk how hard it is to get drugs into Australia (I'm also Aussie) so I'd say try your luck with a doctor, it's probably safer and easier.

As for the meds I've been on, none of them have helped me significantly in the long term. That being said I'm not anti medication and I know several people it has helped. Fluoxetine didn't help but also had no side effects. It basically did nothing. Tastes like shit though.
Sertraline is a different story. When I started it, it caused a manic episode, which I've never experienced before. I nearly jumped a fence onto a highway lol. Also nearly jumped off the roof of a shopping centre. Said some questionable things to people. So start low and go slow.

The worst side effect for me is the withdrawals. They're pretty bad with sertraline and venlafaxine (my current medication). Brain zaps are horrible.

I never had any sexual dysfunction that I could ascribe to the meds. But that being said my depression affects my sex drive anyway. My partner is on a high dose of sertraline and has been for years, and he hasn't had that side effect either. I feel like maybe it's not as common as it seems?

Happy to answer any other questions! And I hope meds work out for you <3
Thanks for the reply. Can I ask what you mean by brain zaps?
As for the GP, I'm skeptical. My current GP won't even prescribe me finasteride for my receding hairline and I'm also not tryna end up in sad jail. Plus I don't think I would be able to afford prescription meds long term, whereas its cheaper on Indiamart.
 
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l1ablemistakes

l1ablemistakes

Wasted potential
Feb 16, 2026
204
Thanks for the reply. Can I ask what you mean by brain zaps?
As for the GP, I'm skeptical. My current GP won't even prescribe me finasteride for my receding hairline and I'm also not tryna end up in sad jail. Plus I don't think I would be able to afford prescription meds long term, whereas its cheaper on Indiamart.
Brain zaps are the main withdrawal symptom for me. Basically if I don't take my meds for a day or two I feel like I'm having a stroke. It's hard to describe. But they honestly arent that expensive. I truly do think it's worth getting meds professionally. Most doctors dont think too hard about prescribing SSRIs unfortunately
 
S

SweetMemories

Member
Dec 30, 2025
74
i was on so many meds i couldnt count. venlafaxine helped the most but the withdrawal was really bad. when i go tinnitus i wanted to go back on venla. [the trial and error thing was almost 2 years] and it did nothing the second time. i am certain i got my tinnitus years later through that. antidepressents are not for me. best thing i had was original lyrica for anxiety.

Was never on Lithium or ketamine though.
 
L

LittleJem

Visionary
Jul 3, 2019
2,738
I recommend trying them, give them twelve weeks to kick in fully etc.
 
sepulchre

sepulchre

Member
Mar 2, 2026
10
Personally, fluoxetine did not take away my suicidal ideation, but it did seriously reduce the physical symptoms of my anxiety. Which is to say, it didn't cure the problem, but it makes being here a lot easier.
 
Luvwww.com

Luvwww.com

Luv
Feb 21, 2026
25
Fluoxetine and Escitopralam, both didn't do anything except making my dick go limp

And the absolute horndog I am, I still found a way to masturbate...
 
rowfish

rowfish

Member
Jul 15, 2025
8
Was thinking of trialling bupropion and sertraline or fluoxetine and seeing if there's any improvement in my mood and motivation, but I've heard the side effects can be detrimental and I want to hear some opinions before I make the financial commitment. The main thing I'm concerned about is worse energy and undesirable mood changes. I'd also prefer if my dick worked but It's not like I really use it anyway so it's manageable. For people who take/have taken antidepressants, did it noticeably improve your mood? How were the side effects?

I'd be ordering the drugs off Indiamart because I don't want to go to a psychiatrist and have my parents aware of my affliction. Not sure how strict border control is in Australia, so hopefully it wouldn't get seized.

If you've had positive experiences with other substances, also open to other suggestions.
i personally recommend sertraline/zoloft! it's effects vary per person but for me there isnt any notable side effects... it really improves my mood and there is an extremely noticeable difference when im on and off my antidepressants(i get REALLY moody and depressed when i forget to take it. wow shocker). it really helps me, so that's why i recommend it
 
etherealgoddess

etherealgoddess

perseverance is inevitable success
Dec 8, 2022
301
Was thinking of trialling bupropion and sertraline or fluoxetine and seeing if there's any improvement in my mood and motivation, but I've heard the side effects can be detrimental and I want to hear some opinions before I make the financial commitment. The main thing I'm concerned about is worse energy and undesirable mood changes. I'd also prefer if my dick worked but It's not like I really use it anyway so it's manageable. For people who take/have taken antidepressants, did it noticeably improve your mood? How were the side effects?

I'd be ordering the drugs off Indiamart because I don't want to go to a psychiatrist and have my parents aware of my affliction. Not sure how strict border control is in Australia, so hopefully it wouldn't get seized.

If you've had positive experiences with other substances, also open to other suggestions.
Sex drive dies. You probably have to use viagra lol. Felt emotionless. But it's better than being suicidal.
 
I

IWillSurvive

Member
Aug 28, 2023
21
Been on vortioxetine for around 5 months now. I was anhedonic, depresonalized quite a bit, very suicidal and felt empty all of the time. Now I feel empty most of the time, I only am suicidal when something triggers it, anhedonia has lowered and depersonalization has increased. Still supposed to be adapting to it. Side effects may have worsened brain fog and suicidal tendencies in the beginning of every dose increase... or maybe it was just depression doing its thing.
 
Webcore

Webcore

Unresolved Emotional Everything
Mar 4, 2026
35
DO NOT GO OFF THEM. I live a life where I unfortunately will always be dependent on anti-depressants, my brain just will never be able to regular those chemicals on its own

So when you feel like "oh I'm better now, I don't need to take them" do not listen to that and keep taking them.
 
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etherealgoddess

etherealgoddess

perseverance is inevitable success
Dec 8, 2022
301
DO NOT GO OFF THEM. I live a life where I unfortunately will always be dependent on anti-depressants, my brain just will never be able to regular those chemicals on its own

So when you feel like "oh I'm better now, I don't need to take them" do not listen to that and keep taking them.
This is so true. You don't want to get off of it because then you're going to have to titrate back on it. It's a mess.
 
BillyBob

BillyBob

Experienced
Jun 14, 2018
230
I am on fluoxetine and Olanzapine. Have been on most of the anti depressants in New zealand that I was pushing for electro compulsive therapy since I qualified when I was younger. Anti depressants are all over the place and take while to sort out since many have such shitty side effects.

Best of luck with them though. They may help and like someone mentioned it will kill your sex drive big time.
 
W

wine is fine but

whiskey's quicker
Jul 26, 2025
201
i am on pristiq (desvenlafaxine) and it has been very positive for me

my doctor prescribed them to me, no psychiatrist necessary, although possibly because i was already on ritalin, that was allowed. do not self medicate. you need to know what you are taking and how it will affect anything else about your life. it is potentially dangerous
 
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pyamu

pyamu

love u so much u guys r the only nice ones left
Dec 14, 2021
45
On zoloft (setraline) but was on escitalopram and bupropion before. Zoloft works very well for me but best in conjunction with a mood-stabilizer. It made me a lot happier overall I think and got rid of a lot of my suicidal ideation. The other two meds did nothing for me other than give me a ton of side effects. I usually hate my meds (zoloft + abilify) because I hate being reliant on them and they make me feel fake. But honestly I might be dead if it weren't for those meds. They definitely made me higher functioning for a while because I had fewer lows.
 
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spoiledberry

spoiledberry

<3
Jul 20, 2025
12
I'm on Zoloft and I've only been on it for a few weeks but I think it has helped a bit because I haven't thought about ctb in a while so that's probably an improvement! I'm still anxious as hell though but It's only been 3 weeks and it takes a while but I think it's helping gradually
 
fatalgarden

fatalgarden

rabbit
Dec 15, 2025
26
Was thinking of trialling bupropion and sertraline or fluoxetine and seeing if there's any improvement in my mood and motivation, but I've heard the side effects can be detrimental and I want to hear some opinions before I make the financial commitment. The main thing I'm concerned about is worse energy and undesirable mood changes. I'd also prefer if my dick worked but It's not like I really use it anyway so it's manageable. For people who take/have taken antidepressants, did it noticeably improve your mood? How were the side effects?

I'd be ordering the drugs off Indiamart because I don't want to go to a psychiatrist and have my parents aware of my affliction. Not sure how strict border control is in Australia, so hopefully it wouldn't get seized.

If you've had positive experiences with other substances, also open to other suggestions.
when i used to take fluoxetine i felt the best i had in years for about 2 weeks, followed by intense panic attacks from about 4 weeks in. i ended up switching to sertraline and im about 5 or 6 weeks in on them and they're far less anxiety inducing. about a couple weeks ago i was feeling way more Awake and able 2 do hobby stuff, this week ive been p lethargic however. i think theyd work for me if my issue was actually depression, like from taking them i can feel that theyre not for me but theyre doing something that would be good if i was depressed
 
woofwag

woofwag

Bad dog
Sep 17, 2025
464
I actually really liked Bupropion before it gave me seizures. But don't let that scare you, I have a VERY low seizure threshold so it's extremely unlikely someone without a pre-existing seizure disorder would get seizures from it. Currently on Lamotrigine. I am still very much depressed. But it helps. It's also meant to be a mood stabilizer, and without it I feel a huge flare in my BPD symptoms.

Also, you can go to a psych without your parents knowing. Confidentiality is a thing, especially since you're an adult
 
vyvanceandvodka

vyvanceandvodka

hoping to recover .✦ ݁˖♡
Jan 7, 2026
202
Prozac changed my life. I was healthy, skinny, successful, in a relationship, and had a great job. I got off of it at the end of 2023 due to traumatic events (falling out with my ex best friend, my biological mom dying, and went through a break up) and I haven't been the same without it. I need to get back on it. It wasn't a "cure all" but it made me function. I miss the old me so much.
 
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perishsong

perishsong

it/she
Sep 10, 2025
87
I was on the exact combo you mentioned - sertraline + bupropion. Only gave me enough push to get out of bed. Switched to fluoxetine + bupropion (XR) - now I have plenty of energy and can maintain it throughout the day. Bupropion is also supposed to mitigate sexual dysfunction brought on by SSRIs. I didn't see any negative changes so far. I def have a decreased appetite and I'm slightly more anxious, but nothing unmanageable. I also sweat a lot but my ANS is also all over the place, so it might be that lol.
 
fleshpuppet

fleshpuppet

Member
Jan 18, 2026
19
Thanks for all the replies. I'm gonna start with bupropion and depending on how I feel after a few months may introduce fluoxetine.
 
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