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Lost1804

Student
Jun 26, 2019
105
Can anyone tell me how much is regarded as a lethal dose of amitriptyline?
In some cases I've read 3g-ish. Others say less or more. The amitriptyline cocktail says 7g, is that just as a certainty?
Does anyone know what a toxicologist would have in his rule book as a lethal dose?
 
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faust

faust

lost among the stars
Jan 26, 2020
3,138
Hello,
LD-50 is a very vague thing which often has nothing common with a real lethal dose.
It depends on your weight, metabolism and many other factors.
That is why it is 7g which will kill everybody. 3 g may not do that to certain people.
 
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L

Lost1804

Student
Jun 26, 2019
105
Hello,
LD-50 is a very vague thing which often has nothing common with a real lethal dose.
It depends on your weight, metabolism and many other factors.
That is why it is 7g which will kill everybody. 3 g may not do that to certain people.
So a toxicology report that states 3 times the lethal dose means the lethal dose for the body they're examining?
 
faust

faust

lost among the stars
Jan 26, 2020
3,138
So a toxicology report that states 3 times the lethal dose means the lethal dose for the body they're examining?
There is some more info, very old info:


"LD-50 on injection, as with many drugs, is lower by a factor of ten . http://www.vh.org//Providers/Conferences/CPS/31.html reports an LD-50 of approx. 35 mg/kg, which correlates more closely with the Merck i.p. LD-50 of 65 mg/kg. The above webpage also says that patients have "survived ingestions of 10g".
 

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