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LastNite

LastNite

Hi
Mar 31, 2025
239
Look on the peaceful pill ehandbook they mention the countries there. Also Nembutal isn't necessary. Just get any strong opioid, they're easier to get and produce a similar peaceful death.
 
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EternalDestiny

Member
May 26, 2025
12
Tijuana Mexico
 
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wham311

Arcanist
Mar 1, 2025
419
Look on the peaceful pill ehandbook they mention the countries there. Also Nembutal isn't necessary. Just get any strong opioid, they're easier to get and produce a similar peaceful death.
Did you see rhizos recent post in the megathread
 
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LastNite

LastNite

Hi
Mar 31, 2025
239
Did you see rhizos recent post in the megathread
uh not really can you link it?

nvm I read some of it but it's a bit too long so I didn't finish it all. What about it though.
 
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wham311

Arcanist
Mar 1, 2025
419
uh not really can you link it?

Per dm

"With a big enough dose taken via the right route of administration of a known drug of known purity if not resuscitated (found) within a certain timeframe, it will work.

However, with the caveat that with genetic tolerance there is a risk that the "big enough dose" in question will need to be astronomical or possibly more than one can reasonably absorb fast enough (given the pharmacokinetic lipid solubility coefficient)

So the margin of error still remains high considering the ceiling for successful ctb is still so high.

I still retain that the effectiveness of this method without medical assistance by a trained professional will always remain low (with improper planning) or moderate at best (with proper planning).

Their statement is true but misleading as it doesn't account for pharmacokinetic factors inherent to ctb attempts. It is only true in terms of pharmacodynamics (assuming X quantity of pure drug has already been absorbed). Risk of injury or failure simply cannot be avoided – only reduced.

For reference, pharmacokinetics = absorption of drug, movement of drug in the body, and excretion of drug. Pharmacokinetics = the concentration of drug in the brain and binding activity in the brain + downstream effects of this activity. Pharmacokinetics precedes the pharmacodynam"ic effect"
 
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LastNite

LastNite

Hi
Mar 31, 2025
239

Per dm

"With a big enough dose taken via the right route of administration of a known drug of known purity if not resuscitated (found) within a certain timeframe, it will work.

However, with the caveat that with genetic tolerance there is a risk that the "big enough dose" in question will need to be astronomical or possibly more than one can reasonably absorb fast enough (given the pharmacokinetic lipid solubility coefficient)

So the margin of error still remains high considering the ceiling for successful ctb is still so high.

I still retain that the effectiveness of this method without medical assistance by a trained professional will always remain low (with improper planning) or moderate at best (with proper planning).

Their statement is true but misleading as it doesn't account for pharmacokinetic factors inherent to ctb attempts. It is only true in terms of pharmacodynamics (assuming X quantity of pure drug has already been absorbed). Risk of injury or failure simply cannot be avoided – only reduced.

For reference, pharmacokinetics = absorption of drug, movement of drug in the body, and excretion of drug. Pharmacokinetics = the concentration of drug in the brain and binding activity in the brain + downstream effects of this activity. Pharmacokinetics precedes the pharmacodynam"ic effect.
I've never heard of genetic tolerance, but it's definitely interesting and I looked it up. It's definitely a thing you'd need to look out for if you eventually choose this path.
It's worrying, but for me I don't really believe that it'll be much of a problem. I've gotten really skinny overtime and the less weight the better in my opinion because there will a higher concentration of the drug in your blood floating around to your brain.


Take a look at this: https://www.nature.com/articles/s41598-022-21003-y

You can summarize it using some random AI tool because it's a lot to go through.
Here's what I got from it:

  • CYP3A4: Gene that makes enzymes breaking down fentanyl faster.
  • CYP3A5: Gene similar to CYP3A4, also breaks down fentanyl faster.
  • ABCB1 (MDR1): Gene that pumps fentanyl out of the brain.
  • OPRM1 A118G: Variant of the mu-opioid receptor gene that reduces receptor response to fentanyl.



Even if you're unlucky enough to have a genetic tolerance to opioids. A large amount of fentanyl will still most likely be effective if you do it in a place where you know people won't come checking in at for a while.

Screenshot 2025 05 31 141805
Screenshot 2025 05 31 141638

This is a recent 2025 National Drug Threat Assessment released by the DEA.

(https://www.dea.gov/sites/default/files/2025-05/2025 National Drug Threat Assessment_Web 5-12-2025.pdf)

"The average purity of fentanyl powder samples was 11.36 percent, ranging from exhibits that contained almost no fentanyl (0.07 percent) to exhibits with an astounding 82 percent purity"
The average has dropped in a couple of years, but it hasn't reached single digits yet. So getting fentanyl that is 1% pure isn't always a common occurrence.

It's always best to test before using. If the purity is very low I'd assume that the test will most likely turn back negative for fentanyl on the first test (Please correct me if I'm wrong). If the purity is average then first test will probably turn out positive. Again this is just an assumption. There's companies out there that have a service for testing the purity of a certain drug and what that substance actually contains. They use Gas Chromatography to test out the purity. It's similar to the one they used in breaking bad if you ever watched the show (https://www.youtube .com/watch?v=6EU-EfKHwY4).


There's a company called energy control based in Spain that lets you send out a sample of 50mg in powder for 120€ to test out both the substance and the purity. Of course, this is very expensive and I think it's not necessary but it's there if you're wondering (https://energycontrol-international.org/drug-testing-service/submitting-a-sample/).
 
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wham311

Arcanist
Mar 1, 2025
419
I've never heard of genetic tolerance, but it's definitely interesting and I looked it up. It's definitely a thing you'd need to look out for if you eventually choose this path.
It's worrying, but for me I don't really believe that it'll be much of a problem. I've gotten really skinny overtime and the less weight the better in my opinion because there will a higher concentration of the drug in your blood floating around to your brain.


Take a look at this: https://www.nature.com/articles/s41598-022-21003-y

You can summarize it using some random AI tool because it's a lot to go through.
Here's what I got from it:

  • CYP3A4: Gene that makes enzymes breaking down fentanyl faster.
  • CYP3A5: Gene similar to CYP3A4, also breaks down fentanyl faster.
  • ABCB1 (MDR1): Gene that pumps fentanyl out of the brain.
  • OPRM1 A118G: Variant of the mu-opioid receptor gene that reduces receptor response to fentanyl.



Even if you're unlucky enough to have a genetic tolerance to opioids. A large amount of fentanyl will still most likely be effective if you do it in a place where you know people won't come checking in at for a while.

View attachment 168242
View attachment 168243

This is a recent 2025 National Drug Threat Assessment released by the DEA.

(https://www.dea.gov/sites/default/files/2025-05/2025 National Drug Threat Assessment_Web 5-12-2025.pdf)


The average has dropped in a couple of years, but it hasn't reached single digits yet. So getting fentanyl that is 1% pure isn't always a common occurrence.

It's always best to test before using. If the purity is very low I'd assume that the test will most likely turn back negative for fentanyl on the first test (Please correct me if I'm wrong). If the purity is average then first test will probably turn out positive. Again this is just an assumption. There's companies out there that have a service for testing the purity of a certain drug and what that substance actually contains. They use Gas Chromatography to test out the purity. It's similar to the one they used in breaking bad if you ever watched the show (https://www.youtube .com/watch?v=6EU-EfKHwY4).


There's a company called energy control based in Spain that lets you send out a sample of 50mg in powder for 120€ to test out both the substance and the purity. Of course, this is very expensive and I think it's not necessary but it's there if you're wondering (https://energycontrol-international.org/drug-testing-service/submitting-a-sample/).
Did you check out the thread? He made an assertion based off coroners report data
 
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LastNite

LastNite

Hi
Mar 31, 2025
239
Did you check out the thread? He made an assertion based off coroners report data
I did read through it but I didn't really understand much. Idk it's either Im really stupid or he just speaks in a way that I cant understand personally.
 
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EternalDestiny

Member
May 26, 2025
12
Is this still easy to do? I thought they cracked down on this several years ago. Otherwise I could easily travel and obtain some there
Yes I was able to about a month ago
 
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