Safety of taking domperidone longer than 48 hours

[Trainwreck]

I asked this in the SN thread, but questions tend to get lost in there. I may need to take domperidone longer than 48 hours, because I will need to cbt on a day my gastroparesis is not acting up horribly. Is that a problem? Just wondering if it's effectiveness diminishes over time. Also, is the last dose just 10mg, or do people use the stat dose of 40mg even if they followed the 48 hour regiment? Thank you!

 

[Stan]

I believe the process is still to use the stat dose. Looking at the drug it actually helps certain types of gastroparesis. side effects include lactation!

 

[gingerplum]

I asked this in the SN thread, but questions tend to get lost in there. I may need to take domperidone longer than 48 hours, because I will need to cbt on a day my gastroparesis is not acting up horribly. Is that a problem? Just wondering if it's effectiveness diminishes over time. Also, is the last dose just 10mg, or do people use the stat dose of 40mg even if they followed the 48 hour regiment? Thank you!

Are you currently being treated with any medication(s) for your gastroparesis?

 

[Trainwreck]

I take the occasional zofran or promethazine. My doc wanted me to take erythromycin or get a Botox injection, but my insurance said no way to both of them. I mostly just don't eat much, and drink nutritional drinks instead of solids.

 

[gingerplum]

I take the occasional zofran or promethazine. My doc wanted me to take erythromycin or get a Botox injection, but my insurance said no way to both of them. I mostly just don't eat much, and drink nutritional drinks instead of solids.

I love that your insurance company gets to decide what's medically necessary. Seriously, I hope those HMO motherfuckers are the first ones up against the wall when the revolution comes.

Jeez, that's just awful that it's so bad you're not even tolerating solids. I'm so sorry.

So. I don't see any significant downside to taking the Domperidone for > 48 hrs; the exception is that it can also affect cardiac contractility, so that is a small possibility.

I can't recall the rules for the stat dose when it follows a 24 or 48 hr regimen. I'd either research it or split the difference and take 20 mg.

I don't see why the effectiveness would diminish over time, especially such a relatively short period. As @Stan noted, it may even help give you some relief from your gastroparesis.

 

[Trainwreck]

I love that your insurance company gets to decide what's medically necessary. Seriously, I hope those HMO motherfuckers are the first ones up against the wall when the revolution comes.

Jeez, that's just awful that it's so bad you're not even tolerating solids. I'm so sorry.

So. I don't see any significant downside to taking the Domperidone for > 48 hrs; the exception is that it can also affect cardiac contractility, so that is a small possibility.

I can't recall the rules for the stat dose when it follows a 24 or 48 hr regimen. I'd either research it or split the difference and take 20 mg.

I don't see why the effectiveness would diminish over time, especially such a relatively short period. As @Stan noted, it may even help give you some relief from your gastroparesis.

Thanks for the kind words! I'm kind of a medical disaster, just one diagnosis after another. Bad genes I guess. That's a good idea, to split the difference on the last dose. I've taken two 5 mg doses so far today, and will try upping to 10 mg tomorrow. Crossing fingers for no negative side effects!

 

[Trainwreck]

I was reading about domperidone (motilium) and came across this:

"Do not take medicines that neutralise or reduce the amount of stomach acid, such as antacids. Do not take medicines that neutralise stomach acid or medicines that reduce the production of stomach acid within 2 hours of taking MOTILIUM. This is because sufficient stomach acid is required to ensure that MOTILIUM is properly absorbed by the body."

Makes me think the last dose, or stat dose, would be rendered completely ineffective since you're taking ranitidine around the same time. Kind of disturbing!

 

[FallenX]

I was reading about domperidone (motilium) and came across this:

"Do not take medicines that neutralise or reduce the amount of stomach acid, such as antacids. Do not take medicines that neutralise stomach acid or medicines that reduce the production of stomach acid within 2 hours of taking MOTILIUM. This is because sufficient stomach acid is required to ensure that MOTILIUM is properly absorbed by the body."

Makes me think the last dose, or stat dose, would be rendered completely ineffective since you're taking ranitidine around the same time. Kind of disturbing!

Is this true? Is an antacid going to make Domperidone ineffective and increase chances of vomiting?

From what I read taking Domperidone with antacids increases the amount of Domperidone absorbed

 

[Lilith81]

Is this true? Is an antacid going to make Domperidone ineffective and increase chances of vomiting?

I am also wondering about this since I can't take meto

 

[onlyinsleep]

I am also wondering about this since I can't take meto

In everything I read about it says not to take it with antiacids and I haven't come up with a solution for that yet. Except Zantac I think can be used. Anyone know how to get Zantac anymore?

 

[FallenX]

In everything I read about it says not to take it with antiacids and I haven't come up with a solution for that yet. Except Zantac I think can be used. Anyone know how to get Zantac anymore?

It's a strong antacid