Help Propofol

[nihilism44]

I'm wondering about propofol as a option for ctb..
To give some background, propofol is used as an anesthetic in both human and vet med. Surprisingly, It is not a controlled substance. The DEA does not monitor usage of propofol AT ALL. It would still be difficult to obtain, but not nearly as difficult as a controlled substance. Nembutal is a schedule 2 controlled substance. 99% of the time, N is ONLY used in vet med for euthanasia(in America), so it is heavily monitored, and both very illegal and pricey to obtain. Propofol causes lack of consciousness and respiratory depression, similar to N. The downside is that it would have to be injected intravenously (which is almost impossible to do without another person present, as you would lose consciousness before being able to finish injection) and I believe it to be extremely short-acting, so I don't think you can use an IV-Drip? I'm just not completely sure of the ins and outs of how death would occur with it. It seems like it would be extremely peaceful if it worked. Anyone with a pharmacy/human med background able to chime in?

Clinical Effects and Lethal and Forensic Aspects of Propofol

Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness. The potential for propofol dependency, recreational use and abuse has only recently been recognized and several cases of accidental overdose and suicide ...

www.ncbi.nlm.nih.gov

 

[Ta555]

I'm wondering about propofol as a option for ctb..
To give some background, propofol is used as an anesthetic in both human and vet med. Surprisingly, It is not a controlled substance. The DEA does not monitor usage of propofol AT ALL. It would still be difficult to obtain, but not nearly as difficult as a controlled substance. Nembutal is a schedule 2 controlled substance. 99% of the time, N is ONLY used in vet med for euthanasia(in America), so it is heavily monitored, and both very illegal and pricey to obtain. Propofol causes lack of consciousness and respiratory depression, similar to N. The downside is that it would have to be injected intravenously (which is almost impossible to do without another person present, as you would lose consciousness before being able to finish injection) and I believe it to be extremely short-acting, so I don't think you can use an IV-Drip? I'm just not completely sure of the ins and outs of how death would occur with it. It seems like it would be extremely peaceful if it worked. Anyone with a pharmacy/human med background able to chime in?

Clinical Effects and Lethal and Forensic Aspects of Propofol

Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness. The potential for propofol dependency, recreational use and abuse has only recently been recognized and several cases of accidental overdose and suicide ...

www.ncbi.nlm.nih.gov

I don't have the background you're looking for but it sounds like it might be hard to use alone? Maybe it could be combined with another method as backup?

 

[intr0verse]

I'm wondering about propofol as a option for ctb..
To give some background, propofol is used as an anesthetic in both human and vet med. Surprisingly, It is not a controlled substance. The DEA does not monitor usage of propofol AT ALL. It would still be difficult to obtain, but not nearly as difficult as a controlled substance. Nembutal is a schedule 2 controlled substance. 99% of the time, N is ONLY used in vet med for euthanasia(in America), so it is heavily monitored, and both very illegal and pricey to obtain. Propofol causes lack of consciousness and respiratory depression, similar to N. The downside is that it would have to be injected intravenously (which is almost impossible to do without another person present, as you would lose consciousness before being able to finish injection) and I believe it to be extremely short-acting, so I don't think you can use an IV-Drip? I'm just not completely sure of the ins and outs of how death would occur with it. It seems like it would be extremely peaceful if it worked. Anyone with a pharmacy/human med background able to chime in?

Clinical Effects and Lethal and Forensic Aspects of Propofol

Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness. The potential for propofol dependency, recreational use and abuse has only recently been recognized and several cases of accidental overdose and suicide ...

www.ncbi.nlm.nih.gov

Re: availability, if you're in the US, you're far more likely to get vet. N than propofol.

 

[little helpers]

funny how I logged back on to Bluelight after YEARS and that place is still alive?! I left the forum thinking everyone has fucking died.

anyways. I checked on Bluelight. the conclusion is you'll wake up if you're doing self-administration. there do be the rare lethal risk unambiguously named "propofol infusion syndrome". but apparently this shit is extremely short-acting and the rare occurrence of the syndrome doesn't happen until after 3 hours of infusion. besides the fact that propofol injections are kind of a pain in the ass to prepare (has to be an emulsion).

so, I don't think it's gonna achieve death.

 

[Sunset Limited]

funny how I logged back on to Bluelight after YEARS and that place is still alive?! I left the forum thinking everyone has fucking died.

anyways. I checked on Bluelight. the conclusion is you'll wake up if you're doing self-administration. there do be the rare lethal risk unambiguously named "propofol infusion syndrome". but apparently this shit is extremely short-acting and the rare occurrence of the syndrome doesn't happen until after 3 hours of infusion. besides the fact that propofol injections are kind of a pain in the ass to prepare (has to be an emulsion).

so, I don't think it's gonna achieve death.

Sorry, that's not true. The toxicity of propofol is related to its blood concentrations. An infusion that can maintain a blood concentration of 30µg/ml will cause the airway to collapse. The propofol infusion rate required for this is probably 8-9 times the upper maintenance limit of 20mg/min. An infusion of this dose causes profound hypotension and circulatory collapse within minutes. Remember the nurses and doctors died with boluses of 50-100mg just to get some sleep. A fast bolus of 200mg probably will kill you without ventilation support and healthcare professionals. Of course, this dose may vary according to the person's body weight, drug addiction and health parameters.

 

[little helpers]

Sorry, that's not true. The toxicity of propofol is related to its blood concentrations. An infusion that can maintain a blood concentration of 30µg/ml will cause the airway to collapse. The propofol infusion rate required for this is probably 8-9 times the upper maintenance limit of 20mg/min. An infusion of this dose causes profound hypotension and circulatory collapse within minutes. Remember the nurses and doctors died with boluses of 50-100mg just to get some sleep. A fast bolus of 200mg probably will kill you without ventilation support and healthcare professionals. Of course, this dose may vary according to the person's body weight, drug addiction and health parameters.

@nihilism44 listen to this guy. I apologize for the misinformation.

 

[nihilism44]

Sorry, that's not true. The toxicity of propofol is related to its blood concentrations. An infusion that can maintain a blood concentration of 30µg/ml will cause the airway to collapse. The propofol infusion rate required for this is probably 8-9 times the upper maintenance limit of 20mg/min. An infusion of this dose causes profound hypotension and circulatory collapse within minutes. Remember the nurses and doctors died with boluses of 50-100mg just to get some sleep. A fast bolus of 200mg probably will kill you without ventilation support and healthcare professionals. Of course, this dose may vary according to the person's body weight, drug addiction and health parameters.

How quickly would a fast bolus of that dose kill you most likely? Is there a risk of waking up, aware, but paralyzed and unable to breathe? That's my worst fear. Like I said before, I'm only familiar with the pharmacodynamics in animals due to my job, so I'm sorry if this seems like a dumb question.

 

[Sunset Limited]

How quickly would a fast bolus of that dose kill you most likely? Is there a risk of waking up, aware, but paralyzed and unable to breathe? That's my worst fear. Like I said before, I'm only familiar with the pharmacodynamics in animals due to my job, so I'm sorry if this seems like a dumb question.

A quick bolus can kill you, but it's still a gamble. I'll do it by infusion. I will put 4000mg of propofol in an IV bag, infuse it with two IV accesses.

 

[KONIJATOR133]

A quick bolus can kill you, but it's still a gamble. I'll do it by infusion. I will put 4000mg of propofol in an IV bag, infuse it with two IV accesses.

Would be a Quick infusion of 25ml (250mg) be enough ?

 

[Sunset Limited]

Would be a Quick infusion of 25ml (250mg) be enough ?

Although rapid boluses are dangerous, they do not offer a guarantee for CTB. It depends on your age, health parameters, weight, airway, drug addiction. Health professionals have died with far less, but still, there is no guarantee.