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paparoach

Member
Jan 28, 2025
11
Hi all,

We know that all suicide methods of poisoning ingestion should be accompanied by an anti-emetic, with the PPHB recommending Metoclopramide, Domperidone, Prochlorperazine and Stan's Guide additionally recommending Olanzapine, Alizapramide, Chlorpromazine.

As has been pointed out before, these anti-emetics are potentially harder to source as they are Over-The-Counter or Prescription-Only-Medicines, which require lieing to a Dr or Pharmacist that deals with hundreds of people a week and can spot a liar, knows these specialist medicines may well be developing a reputation for niche use, or just potentially cost multiple times the SN from a dodgy offshore website.

The only anti-emetic I have easy ecommerce access to is Promethazine. No need to lie about symptoms, no face to face interactions, no insane costs.

Whilst I have found user KRSU's post here a very good discussion, I don't believe Promethazine is discussed enough as,
  • Both Promethazine and the traditionally recommended Prochorperazine are both anti-emetics of the Phenothiazines family, that work by blocking dopamine and serotonin receptors in the brain.
  • It's medical uses include sedation, anxiety before surgery, and to treat short-term insomnia.
  • A typical dose of 10mg Metoclopramide is often considered roughly equivalent to a 25mg dose of Promethazine
  • Ultimately, I don't believe any anti-emetic is going to stop you from vomitting: everyone vomits. Anecdotal. But there is no escpaing the fact your body is going to try eject the poison, whether you're conscious or not.
Apart from people not wanting to deviate from respected sources, what am I missing here about promethazine as a substitute?

Any and all consideration and contribution welcome,
-p
 
Last edited:

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