Water crisis will begin to come into full swing in certain parts of the world (i.e. Middle East, North Africa, parts of India & China, etc.). Upstream countries will exploit downstream countries and fuel tensions among an already fractured geopolitical region. Reservoirs will likely become a target of interest by terrorists.
The launch of the James Webb Space Telescope will be postponed again because why the fuck not.
COVID-19 will be with us for a long time, but nature will prefer less virulent strains to prosper. It will be treated as the seasonal flu. Assuming the virus hasn't mutated considerably, and this new strain hopefully burns out, initial rollout of vaccines will be slow, but expect roughly 40-50% of the world to have received their vaccines by July (don't quote me on this).
Brood X will reemerge in the eastern US, and everyone will be pissed off.