Tramadol is a comparatively weak opioid, but overdose is still possible. A person's tolerance and genetics have a significant influence on their tramadol overdose risk.
The amount of tramadol it takes to overdose depends both on the person's tolerance for the drug and genetics.
Overdose deaths from opioids like tramadol were responsible for claiming more than 14,000 American lives in 2019,
Doctors recommend that patients take no more than 50 mg of short-acting tramadol every six hours as needed, or 100 mg of long-acting tramadol per day when starting out. This amount may be increased as tolerances do. However, the max dose of the drug is 300 mg a day for the short-acting formulation and 400 mg a day for the long-acting formulation.
Tramadol Overdose Mg
There is no exact milligram amount of tramadol that can cause an overdose. The amount of tramadol it takes to overdose depends on the person and is linked to both tolerance and genetics.
Tolerance means the amount of drug that your body is used to. For example, if you regularly take 50 mg of tramadol and suddenly increase to 400 mg, your risk for an overdose increases.
Genetics also plays a big role in tramadol overdose. Tramadol is broken down by an enzyme called CYP2D6 in the liver. However, some people have genes for a more active form of this enzyme than other people. In turn, tramadol may be far more potent than expected in some people and may be less potent than expected in others.
