Please get domperidone, not metoclopramide

[Huggs]

I don't have any money and spent a precious amount on metoclopramide which I will likely now need to use despite how much it could mess with my attempt.

I tried only 10mg today and my legs became slightly twitchy and stiff, EPS symptoms, which is alarming because you don't want to be experiencing that while attempting, it could lead to terrible mistakes. Hours later I had auditory and visual hallucinations while starting to fall asleep which I never really had before. I've also woken up after finally managing to fall asleep and am having trouble sleeping even though I'm exhausted.

I naively thought meto was more effective than domperidone but from what I've seen they apparently have the same potency.

Some studies:

S0473 Domperidone Is Superior Compared With Metoclopramide... : Official journal of the American College of Gastroenterology | ACG

An abstract is unavailable.

journals.lww.com

https://deepblue.lib.umich.edu/bitstream/handle/2027.42/74548/j.1572-0241.1999.00456.x.pdf

https://www.researchgate.net/publication/22623644_Domperidone_or_metoclopramide_in_preventing_chemotherapeutically_induced_nausea_and_vomiting

Europe PMC

Europe PMC is an archive of life sciences journal literature.

europepmc.org

 

[Innereye]

metoclopramide is literally poison to me, makes me so sick.

 

[Banshe]

For me I pass out at about t+40 minutes 30mg meto ingestion. I plan to use that to boost the peacefulness of my method.

 

[Unknown21]

Thankfully, i have both.

 

[cscott]

Thankfully, i have both.

Does domperidone make u poop? I feel I had that side effect.. did look it up and said might cause some bowel movements ..so wondering for you ?

 

[Unknown21]

I didn't test it tho, but may I'll test it soon.

 

[toofargone6969]

Yes, I came to the same conclusion. Domperidone is just as effective without the risks of meto. It can be purchased without a prescription from IHP, an online pharmacy that ships from Vanuatu. It's banned in the US so unavailable on prescription.

 

[Huggs]

Forgot to mention and can't edit: it's theorized that a percentage of people can get hallucinations because of the following:

"Chronic administration of a dopamine antagonist (e.g., metoclopramide) might induce dopamine receptor supersensitivity. It is hypothesized that exacerbation or occurrence of psychotic symptoms following neuroleptic withdrawal results from mesolimbic dopamine supersensitivity."

Metoclopramide-induced supersensitivity psychosis

hub.tmu.edu.tw

It applies to domperidone too and this wouldn't be a problem because you should be unconscious by then, but still something to know I'd say.

 

[LaVieEnRose]

Forgot to mention and can't edit: it's theorized that a percentage of people can get hallucinations because of the following:

"Chronic administration of a dopamine antagonist (e.g., metoclopramide) might induce dopamine receptor supersensitivity. It is hypothesized that exacerbation or occurrence of psychotic symptoms following neuroleptic withdrawal results from mesolimbic dopamine supersensitivity."

Metoclopramide-induced supersensitivity psychosis

hub.tmu.edu.tw

It applies to domperidone too and this wouldn't be a problem because you should be unconscious by then, but still something to know I'd say.

That specifically says "chronic administration" though. Not that it can't happen but just based on this citation alone...

 

[Huggs]

That specifically says "chronic administration" though. Not that it can't happen but just based on this citation alone...

Good point! Yes, it probably isn't an issue. However I was curious because I myself experienced some hallucinations from the 10 mg as I started falling asleep hours later.

 

[LaVieEnRose]

Good point! Yes, it probably isn't an issue. However I was curious because I myself experienced some hallucinations from the 10 mg as I started falling asleep hours later.

Were you familiar with meto's side effect profile before you took it? Is it possible you psyched yourself out and almost "forced" yourself to perceive them?

 

[Huggs]

Were you familiar with meto's side effect profile before you took it? Is it possible you psyched yourself out and almost "forced" yourself to perceive them?

I was aware of EPS but not hallucinations, they look to be rare.

 

[Kasumi]

Meto should never be used for more than short-term and you shouldn't take more than the max recommended dose (I don't remember if it was 60mg or 120mg daily).
But in some cases people report hallucinations or seizures even from their first use.
Not a point of concern imo if u're going to die anyway, but def something to keep in mind if people take it for nausea or migraines.

 

[William01]

It's the only AE I have so guess I'll be sticking with it

 

[Wants-To-End]

I don't have any money and spent a precious amount on metoclopramide which I will likely now need to use despite how much it could mess with my attempt.

I tried only 10mg today and my legs became slightly twitchy and stiff, EPS symptoms, which is alarming because you don't want to be experiencing that while attempting, it could lead to terrible mistakes. Hours later I had auditory and visual hallucinations while starting to fall asleep which I never really had before. I've also woken up after finally managing to fall asleep and am having trouble sleeping even though I'm exhausted.

I naively thought meto was more effective than domperidone but from what I've seen they apparently have the same potency.

Some studies:

S0473 Domperidone Is Superior Compared With Metoclopramide... : Official journal of the American College of Gastroenterology | ACG

An abstract is unavailable.

journals.lww.com

https://deepblue.lib.umich.edu/bitstream/handle/2027.42/74548/j.1572-0241.1999.00456.x.pdf

https://www.researchgate.net/publication/22623644_Domperidone_or_metoclopramide_in_preventing_chemotherapeutically_induced_nausea_and_vomiting

Europe PMC

Europe PMC is an archive of life sciences journal literature.

europepmc.org

Even I had same experience with it , i never know that meto will have such a phycological effect , it made me helpless in both physical and emotional way, If i had seen this post earlier I would have bought "domperidone" instead of Meto - If this meto have such a bad effect on people, how does it became first choice of Antiemetic in this site ? I have no clue