Method Nortriptyline sub for Amitriptyline

[akwa]

I don't think I'ma find SN anytime soon, but I do have nearly 10g of Nortriptyline, couple hundred of Amitriptyline, some propranolol, 3g of Xanax, and a bunch of zofran.

I'm thinking I could CTB, it's just not how I wanted to go necessarily as it seems less reliable than SN.

But is 10g of Nortriptyline equivalent to the 10g of Amitriptyline noted as lethal in the PPH?

I really don't want to fuck this up.

Not sure when, but I absolutely need something ready to go right now. Also considering firearm, but something about lying back and drifting off to find peace seems a bit better. I've not really found peace in my life before, so finding it in death is is something I desire.

But I've not necessarily ruled out a firearm.

Thanks for the add to this website.

 

[rotciv]

It is a little more than half the potency of amitriptyline.

 

[sanitystruggle]

It is a little more than half the potency of amitriptyline.

Do you have a source for that? The dosing guides and maximum daily dose are virtually identical:

Nortriptyline vs. Amitriptyline: What's the Difference?

Nortriptyline and amitriptyline are orally administered tricyclic antidepressants (TCAs) used to treat major depressive disorder (MDD) or, in an off-label setting, nerve pain or migraine prevention. While similar, they carry notable differences potential users should understand.

www.verywellhealth.com

Amitriptyline is metabolised into nortriptyline in the body and studies have shown higher total plasma TCA levels for the latter:

A Comparison Study of Amitriptyline and Nortriptyline With Plasma Levels

• Forty-one depressed outpatients were treated for six weeks after random assignment to amitriptyline hydrochloride (N = 22) or nortriptyline hydrochloride (N = 19). On a mean daily dose of 119 mg, amitriptyline-treated patients had a mean tricyclic level (amitriptyline plus nortriptyline) of 120...

jamanetwork.com

 

[rotciv]

Do you have a source for that? The dosing guides and maximum daily dose are virtually identical:

Nortriptyline vs. Amitriptyline: What's the Difference?

Nortriptyline and amitriptyline are orally administered tricyclic antidepressants (TCAs) used to treat major depressive disorder (MDD) or, in an off-label setting, nerve pain or migraine prevention. While similar, they carry notable differences potential users should understand.

www.verywellhealth.com

Amitriptyline is metabolised into nortriptyline in the body and studies have shown higher total plasma TCA levels for the latter:

A Comparison Study of Amitriptyline and Nortriptyline With Plasma Levels

• Forty-one depressed outpatients were treated for six weeks after random assignment to amitriptyline hydrochloride (N = 22) or nortriptyline hydrochloride (N = 19). On a mean daily dose of 119 mg, amitriptyline-treated patients had a mean tricyclic level (amitriptyline plus nortriptyline) of 120...

jamanetwork.com

Although amitriptyline converts to nortriptyline in the body, amitriptyline is clearly more deadly than nortriptyline, but I don't know why.

 

[losing hope]

Can Nortriptyline or Amitriptyline be purchased over the DW? Or Better yet anywhere on the clear net?

Not asking for sources just want to know if this is an option for me?

 

[sanitystruggle]

Although amitriptyline converts to nortriptyline in the body, amitriptyline is clearly more deadly than nortriptyline, but I don't know why.

View attachment 137944View attachment 137945

Interesting - studies in humans consistently rate nortriptyline as having a lower minimum toxic dose than amitriptyline, e.g.:

https://www.tandfonline.com/doi/full/10.1080/15563650701226192

Which reports 5mg/kg for TCAs generally but singles out desipramine, nortriptyline, trimipramine, and protriptyline as being 1-2.5mg/kg.

 

[rotciv]

Interesting - studies in humans consistently rate nortriptyline as having a lower minimum toxic dose than amitriptyline, e.g.:

https://www.tandfonline.com/doi/full/10.1080/15563650701226192

Which reports 5mg/kg for TCAs generally but singles out desipramine, nortriptyline, trimipramine, and protriptyline as being 1-2.5mg/kg.

I'll take a better look, thanks.