New novel treatment for depression

[Taylor]

I was just scrolling through all the Snapchat news stories and saw that the FDA just approved "Esketamine" which is essentially clinical Ketamine in the form of a nasal spray, that supposedly works on a different brain chemical known as Glutamate, and the effects are almost instantaneous, in just a few hours, rather than waiting for weeks to months to kick in like traditional antidepressants. Just thought I'd post this news if any of you are here solely due to symptoms of depression, without any external cause.

 

[Hopeless_soul]

That's always good news, man. But, for instance, in my case, I have such an addictive personality, I wouldn't risk it. I was reading about this today

https://www.cbsnews.com/amp/news/fda-designates-mdma-as-breakthrough-therapy-for-ptsd/

It sounds promising, but I know I can't add up another addition to my list. It'd make my life worst.

You think it's ok to take the risk?

 

[Hopeless_soul]

addition to my list. It'd make my life worst.

Mistakes there: Addiction*, worse * lol had to say that.

 

[Taylor]

That's always good news, man. But, for instance, in my case, I have such an addictive personality, I wouldn't risk it. I was reading about this today

https://www.cbsnews.com/amp/news/fda-designates-mdma-as-breakthrough-therapy-for-ptsd/

It sounds promising, but I know I can't add up another addition to my list. It'd make my life worst.

You think it's ok to take the risk?

I read something in the article that did mention the risk for addiction and abuse, but then it also mentioned it would be highly controlled, assuming your physician or psychiatrist could only administer so much at a given time, to prevent dependency.

 

[Taylor]

Mistakes there: Addiction*, worse * lol had to say that.

Lol, I get it, I'm a grammatical perfectionist myself

 

[Hopeless_soul]

English is not my native language, but I am enthusiastic about it. Lol.

 

[Hopeless_soul]

I read something in the article that did mention the risk for addiction and abuse, but then it also mentioned it would be highly controlled, assuming your physician or psychiatrist could only administer so much at a given time, to prevent dependency.

Yeah, in the end, it always depends on your personal situation. What you are willing to risk, etc.

 

[Taylor]

English is not my native language, but I am enthusiastic about it. Lol.

Omg well you're doing a better job than I ever could at a second language! Haha

 

[Taylor]

Yeah, in the end, it always depends on your personal situation. What you are willing to risk, etc.

Yeah they said in this case, the benefits would clearly outweigh the risks, and I agree with them...lol.

 

[Hopeless_soul]

Omg well you're doing a better job than I ever could at a second language! Haha

I can read in English and write, but I have issues with prepositions... After so many years, I still struggle with them. Jesus.

Yeah they said in this case, the benefits would clearly outweigh the risks...lol.

Always have to ponder that, yeah. I wish I could be myself without anything. I have to get used to the idea that I need something, yeah....

 

[dysfunctional]

I might ask about this at my next appointment...

 

[Hopeless_soul]

I might ask about this at my next appointment...

So do I.

 

[xXSarac3nSlay3rXx]

https://www.google.com/amp/s/tonic....kzkje/dxm-cough-syrup-antidepressant-ketamine

On a related note, you can buy dxm at the supermarket. I have no idea what doses would be therapeutic, but apparently it may work like ketamine. I'm tempted to try using this.

 

[Pentobartbital]

https://www.google.com/amp/s/tonic....kzkje/dxm-cough-syrup-antidepressant-ketamine

On a related note, you can buy dxm at the supermarket. I have no idea what doses would be therapeutic, but apparently it may work like ketamine. I'm tempted to try using this.

Be careful. I would make extra sure you utilise an online dose calculator to get a general estimation of the "plateau" or desired height of effect you wish for (I, II, III and so on, with Sigma being highest.) While dextromethorphan is chemically similar in that it's a dissociative, you need to also space out doses each fortnight for safety reasons. And remember: if you can't say no, just stay low!

@Taylor

I've heard this is an increasingly popular treatment, especially for those who conventional drugs cannot assist (like returning combat veterans from the occupations in western Asia.) Yet the one thing that worries me is the ramification of Olney's lesions, which are essentially tiny holes that develop in the brain after continual use. These can pose cognitive issues and are present in most if not all dissociatives like ketamine or DXM.

 

[311]

I have ketamine nasal spray. It works well but it wears off quickly

 

[About_to_Go]

I have ketamine nasal spray. It works well but it wears off quickly

How do you seemingly have access to every drug except amitriptyline? Lol

 

[311]

How do you seemingly have access to every drug except amitriptyline? Lol

I'm prescribed it for depression. I take 50mg everynight and a lozenge for the day.

I'm on
Soma
Valium
Amphetamine
Modafanil
Lyrica
Clonidine
Abilify

Nice cocktail. I hate my life

 

[WhiteRabbit]

I've done ketamine infusions (through an IV) for chronic pain, but they also use them for depression. It didn't help me with either one.

 

[311]

I've done ketamine infusions (through an IV) for chronic pain, but they also use them for depression. It didn't help me with either one.

Not even for a little bit during the infusion?

 

[Jenna]

I saw that on the news this morning and was curious too.

 

[cornflowerblue]

Regular ketamine is made up of esketamine and arketamine, and that's been available for a while. You can search google for ketamine clinics, they've been popping up like crazy.

Esketamine will be brand name and there will be a special program you and your doctor have to sign up for. On the FDA paperwork, it says you'll have to do the dose in the doctors office and then sit there for 2 hours after before leaving. No take home meds, so unless you have illegal ketamine sources, I don't think it would make addiction problems

 

[WhiteRabbit]

Not even for a little bit during the infusion?

I was tripping balls and pretty happy during the infusion, but it all went away after it ended. I didn't have any lasting results, but some people do. If it works you usually have to get "booster" treatments every couple of months and it's pretty expensive.

 

[StGerman]

I have ketamine nasal spray. It works well but it wears off quickly

Really? Can you already buy it? Where are you located? US or Europe?

 

[311]

Really? Can you already buy it? Where are you located? US or Europe?

US.

 

[lululoo]

The study results as described in a NYT article about this didn't seem too great. But I guess no depression treatment really has great effects.

The other thing is, you have to be on a regular antidepressant too. I don't want to go back on those. They don't help me. I mean I guess you could get the prescription and just lie and not take it.

As for addiction, I don't think this is at doses where you trip or get any euphoric effects. So it seems unlikely that you would do this and like it so much that you start buying ketamine on the black market. I can't say for sure though as I'm not someone who gets addicted easily.

Like @WhiteRabbit I tried the infusions for pain and they didn't help my pain or depression.

 

[RememberWhatUCameFor]

why is ketamine illegal and alcohol not?

 

[311]

why is ketamine illegal and alcohol not?

Cultural

 

[StGerman]

I get also treated with Ketamine but intravenous and it has an effect although it doesn't last that longue

 

[Anima]

Clinical studies have yet to prove the effects of ketamine. Plus, it's quite expensive ...

 

[xXSarac3nSlay3rXx]

Be careful. I would make extra sure you utilise an online dose calculator to get a general estimation of the "plateau" or desired height of effect you wish for (I, II, III and so on, with Sigma being highest.) While dextromethorphan is chemically similar in that it's a dissociative, you need to also space out doses each fortnight for safety reasons. And remember: if you can't say no, just stay low!

@Taylor

I've heard this is an increasingly popular treatment, especially for those who conventional drugs cannot assist (like returning combat veterans from the occupations in western Asia.) Yet the one thing that worries me is the ramification of Olney's lesions, which are essentially tiny holes that develop in the brain after continual use. These can pose cognitive issues and are present in most if not all dissociatives like ketamine or DXM.

Is there any risk of developing Olney's lesions if something like dxm is used moderately? An article I was reading (https://wiki.tripsit.me/wiki/DXM) recommends that you take a break of at least 1 week per plateau between doses. Is there any risk of damage if I use it in this way?