Nembutal & Antipsychotics

[virtualoctopus]

There is surprisingly little information on the interactions between pentobarbital and antipsychotic medications. It it generally understood that there is an interaction, but the timeline is always unspecefic. The PPH says that "a few days" discontinuation is sufficient, while other sources state a month, or even a years abstinence is necessary to avoid complications. WTF. I know there isn't much information out there, and obviously the subject hasn't been researched enough, but does anyone know ANYTHING that might be helpful? It's been about 2 weeks since I've stopped taking Zyprexa, and I'm wondering at what point can I safely say that it has left my system enough for Nembutal to be an effective agent? I've been taking it for several years, so without a doubt it's had a chance to in bed itself in my liver. From what I've been able to gather, prolonged use of antipsychotics dramatically increases the chance of extended barbiturate coma a raises the time of death by 22 hours. I am greatly troubled.

Help!

 

[Secrets1]

There is surprisingly little information on the interactions between pentobarbital and antipsychotic medications. It it generally understood that there is an interaction, but the timeline is always unspecefic. The PPH says that "a few days" discontinuation is sufficient, while other sources state a month, or even a years abstinence is necessary to avoid complications. WTF. I know there isn't much information out there, and obviously the subject hasn't been researched enough, but does anyone know ANYTHING that might be helpful? It's been about 2 weeks since I've stopped taking Zyprexa, and I'm wondering at what point can I safely say that it has left my system enough for Nembutal to be an effective agent? I've been taking it for several years, so without a doubt it's had a chance to in bed itself in my liver. From what I've been able to gather, prolonged use of antipsychotics dramatically increases the chance of extended barbiturate coma a raises the time of death by 22 hours. I am greatly troubled.

Help!

I'm sorry this is bothering you. 3 days vs 2 weeks will make a considerable difference and I would not expect a large interaction at this point (although I am not certain). Zyprexas average half life is about 33 hours so let's just say every 1.5 days the amount of the drug remaining in your system gets cut in half. After 15 days you'll have less than 1% of the zyprexa in your bloodstream than when you last took it.

 

[loopylou]

Wish I knew the answer to this. I need my meds to sleep. Don't fancy two days of no sleep before ctb never mind two weeks

 

[Thegoldenapples]

Antipsychotics are 'lipophilic' and can become stored in body fats, but i think with N, it's more about how your liver processes it. I personally wouldn't worry. Some half life's can be up to 39 days, but your one is 21 to 54 hours so that's quite low. Think PPH didn't mention too much about it because they don't find it to be a big deal. I've seen the month suggestion somewhere too. Maybe that was because the half life are differnt. Idk. Just make sure you're not found within a decent 24 hours if you can and if you have two bottles, I don't see a chance of surviving if you follow protocol. I think people in those meds will still be fine taking N and cbt, they just need to make sure a decent amount of time of left after ingestion.

 

[loopylou]

Antipsychotics are 'lipophilic' and can become stored in body fats, but i think with N, it's more about how your liver processes it. I personally wouldn't worry. Some half life's can be up to 39 days, but your one is 21 to 54 hours so that's quite low. Think PPH didn't mention too much about it because they don't find it to be a big deal. I've seen the month suggestion somewhere too. Maybe that was because the half life are differnt. Idk. Just make sure you're not found within a decent 24 hours if you can and if you have two bottles, I don't see a chance of surviving if you follow protocol. I think people in those meds will still be fine taking N and cbt, they just need to make sure a decent amount of time of left after ingestion.

How do you find out how long each drug takes to leave the system? I'm on a few. Also as you said they can become stored in body fats, I wonder if that's why I physically can't lose weight too

 

[Secrets1]

How do you find out how long each drug takes to leave the system? I'm on a few. Also as you said they can become stored in body fats, I wonder if that's why I physically can't lose weight too

Google the drug and it's half life. That gives a range for active metabolism time which is all encompassing. The unknown unless measured is how much you start with. However once playing around with half life calculations you can see how the density decreases so dramatically over time. Unless you're dealing with a month long half life, jeez. I haven't read about a drug like that yet. Personally, I'd feel comfortable after a day or so like the above poster stated but I'm also not worried about coma with N.

 

[Thegoldenapples]

How do you find out how long each drug takes to leave the system? I'm on a few. Also as you said they can become stored in body fats, I wonder if that's why I physically can't lose weight too

Yeah a lot do gain weight. I was on Risperidone for about 4 months and gained 10kgs. A lot more hungry and it's messes with your endocrine system which regulates hormones and metabolism. Weight loss is hard on them, goes back to normal once you're off.

 

[BobMorane]

You just have to check the half life of your AP. Or just check on internet how many days it stays in your system. For example, I take Latuda (AP that interacts with N) and Wellbutrin (AD that interacts with Metoclopramide). Both take 6 days to wash off your system. So I plan to wait 6 days (and pray I dont have another psychosis) and then book 2 nights at the best hotel in town (in case my coma expands to more than 24 hours) and then take the N as I watch the view over the window and listen to my favorite music and sip on a cup of Bailey. Thats my plan.

 

[ihateantipsychotics]

I'm also curious. I have ordered N from D but I'm worried about my antipsychotics history. I've been off for 3 months though, but my receptors are fucked up by AP, so I wonder if 2 bottles of Nembutal are enough to do the job…

 

[whatintheworld365]

I'm also curious. I have ordered N from D but I'm worried about my antipsychotics history. I've been off for 3 months though, but my receptors are fucked up by AP, so I wonder if 2 bottles of Nembutal are enough to do the job…

Wish I knew the answer to this. I need my meds to sleep. Don't fancy two days of no sleep before ctb never mind two weeks

I am wondering the same. I take seroquel to sleep each night but fear not sleeping at all leading up to my ctb will derail my plans. Ugh

 

[hankbank3928]

Bump.
Was just wondering if anyone could reassure me as I'm forced to take antipsychotics right now but I still want to ctb with N. Do you think I should worry?

 

[bing]

Pretty sure it would work fine if you took N with an antipsychotic