Discussion Meto vs domp

[Eudaimonic]

Metoclopramide has anti-serotoninergic effects on the 5HT3 and 5HT4 receptors. Domperidone does not, though both antagonize the D2 receptor and speed gastric emptying.

Is it better to take meto instead because of its anti-serotonergic effects?

I've thought about combining meto, ondansetron, and mosapride, but maybe that's inferior to just taking meto.

Also, what about meto + ondansetron combo?

 

[martinso67]

Metoclopramide has anti-serotoninergic effects on the 5HT3 and 5HT4 receptors. Domperidone does not, though both antagonize the D2 receptor and speed gastric emptying.

Is it better to take meto instead because of its anti-serotonergic effects?

I've thought about combining meto, ondansetron, and mosapride, but maybe that's inferior to just taking meto.

Also, what about meto + ondansetron combo?

No medical recommendations, you have to decide yourself.
I did think of the combination of meto and ondansetron. I did research and lookup studies of the usage of this combination on the intetnet.
It said that the combination of this two medication did work better with 0% vomiting rate and 4% in 24 hours. While meto only had about 40%.

https://www.researchgate.net/publication/288301170_The_anti-emetic_efficacy_of_a_combination_of_ondansetron_and_metoclopramide

Also saw no offical mention of interaction between the two medications.
I thought of it as a better alternative to the stan protocol that makes me take meto for two days before the "CTB action". Because of worried of neurologic (uncontrolled muscle movements) that can happen as a rare side effect. This side effect though happens after 12 hours and usually during regular use.

 

[Forveleth]

In the PPH, April 2022 edition, they recommend meto because it helps with gastric emptying meaning it encourages your stomach to empty so there is less chance of vomiting.

However, any antiemetic will do fine. Work with what you can get. People have been successful without one too, so it is not essential.

 

[Eudaimonic]

Metoclopramide has anti-serotoninergic effects on the 5HT3 and 5HT4 receptors. Domperidone does not, though both antagonize the D2 receptor and speed gastric emptying.

Is it better to take meto instead because of its anti-serotonergic effects?

I've thought about combining meto, ondansetron, and mosapride, but maybe that's inferior to just taking meto.

Also, what about meto + ondansetron combo?

shit, this should say "domp, ondansetron, and mosapride"

 

[ijustwishtodie]

I'm personally going to use domperidone because that is what I could access easily. I don't know which one is better but I doubt that there is such a significant difference between both of the anti emetics to where one is definitely preferred over the other. If that was the case, I feel like that would be clearly established by the members on this site who have collated information about SN over the years

 

[martinso67]

I'm personally going to use domperidone because that is what I could access easily. I don't know which one is better but I doubt that there is such a significant difference between both of the anti emetics to where one is definitely preferred over the other. If that was the case, I feel like that would be clearly established by the members on this site who have collated information about SN over the years

Domperidone is actually also recommended as an alternative to meto. But its also mentioned as a recommendation in the book final exit (alternative to PPEH) for people afraid of rare neurological side effects of meto.

 

[Eudaimonic]

I'm personally going to use domperidone because that is what I could access easily. I don't know which one is better but I doubt that there is such a significant difference between both of the anti emetics to where one is definitely preferred over the other. If that was the case, I feel like that would be clearly established by the members on this site who have collated information about SN over the years

This is a good point. It's also a much different use case than those that any studies concerned.