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Eudaimonic

Eudaimonic

I want to fade away.
Aug 11, 2023
829
Metoclopramide has anti-serotoninergic effects on the 5HT3 and 5HT4 receptors. Domperidone does not, though both antagonize the D2 receptor and speed gastric emptying.

Is it better to take meto instead because of its anti-serotonergic effects?

I've thought about combining meto, ondansetron, and mosapride, but maybe that's inferior to just taking meto.

Also, what about meto + ondansetron combo?
 
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martinso67

All human rights are important
Feb 5, 2021
317
Metoclopramide has anti-serotoninergic effects on the 5HT3 and 5HT4 receptors. Domperidone does not, though both antagonize the D2 receptor and speed gastric emptying.

Is it better to take meto instead because of its anti-serotonergic effects?

I've thought about combining meto, ondansetron, and mosapride, but maybe that's inferior to just taking meto.

Also, what about meto + ondansetron combo?
No medical recommendations, you have to decide yourself.
I did think of the combination of meto and ondansetron. I did research and lookup studies of the usage of this combination on the intetnet.
It said that the combination of this two medication did work better with 0% vomiting rate and 4% in 24 hours. While meto only had about 40%.


Also saw no offical mention of interaction between the two medications.
I thought of it as a better alternative to the stan protocol that makes me take meto for two days before the "CTB action". Because of worried of neurologic (uncontrolled muscle movements) that can happen as a rare side effect. This side effect though happens after 12 hours and usually during regular use.
 
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Forveleth

I knew I forgot to do something when I was 15...
Mar 26, 2024
1,532
In the PPH, April 2022 edition, they recommend meto because it helps with gastric emptying meaning it encourages your stomach to empty so there is less chance of vomiting.

However, any antiemetic will do fine. Work with what you can get. People have been successful without one too, so it is not essential.
 
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Eudaimonic

Eudaimonic

I want to fade away.
Aug 11, 2023
829
Metoclopramide has anti-serotoninergic effects on the 5HT3 and 5HT4 receptors. Domperidone does not, though both antagonize the D2 receptor and speed gastric emptying.

Is it better to take meto instead because of its anti-serotonergic effects?

I've thought about combining meto, ondansetron, and mosapride, but maybe that's inferior to just taking meto.

Also, what about meto + ondansetron combo?
shit, this should say "domp, ondansetron, and mosapride"
 
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ijustwishtodie

ijustwishtodie

I have finally found my ultimate bliss
Oct 29, 2023
5,803
I'm personally going to use domperidone because that is what I could access easily. I don't know which one is better but I doubt that there is such a significant difference between both of the anti emetics to where one is definitely preferred over the other. If that was the case, I feel like that would be clearly established by the members on this site who have collated information about SN over the years
 
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martinso67

All human rights are important
Feb 5, 2021
317
I'm personally going to use domperidone because that is what I could access easily. I don't know which one is better but I doubt that there is such a significant difference between both of the anti emetics to where one is definitely preferred over the other. If that was the case, I feel like that would be clearly established by the members on this site who have collated information about SN over the years
Domperidone is actually also recommended as an alternative to meto. But its also mentioned as a recommendation in the book final exit (alternative to PPEH) for people afraid of rare neurological side effects of meto.
 
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Eudaimonic

Eudaimonic

I want to fade away.
Aug 11, 2023
829
I'm personally going to use domperidone because that is what I could access easily. I don't know which one is better but I doubt that there is such a significant difference between both of the anti emetics to where one is definitely preferred over the other. If that was the case, I feel like that would be clearly established by the members on this site who have collated information about SN over the years
This is a good point. It's also a much different use case than those that any studies concerned.
 
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