Methemoglobin cannot carry oxygen NOR carbon dioxide.

[littlelady774]

I was reading this article : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497199/#sec-1title

And it said methemoglobin cannot carry carbon dioxide -which is worrying because it will build up in the body's tissues in the form of lactic acid. This is what causes shortness of breath with SN. Since the methemoglobin cannot transport carbon dioxide to the lungs to expel it all, it may not feel like suffocation, per se, but breathlessness, like from really intense exercise.

Thoughts? Anyone correct me if I'm wrong

 

[pthnrdnojvsc]

No there are other ways carbon dioxide expelled. The many sn threads i read I don't remember anyone saying suffocating even survivors of sn 2019 2020.all survivors then said painless.

. Also peaceful pill has observed many sn suicides all peaceful but one a very old person. I held breath before suffocating extremely painful no sign of this kind of pain w sn

 

[Obliviate]

I agree with the comment above, I will do more research but so far I have learned that there are other ways that CO2 can be expelled because it is not being primarily used with hemoglobin maybe that is why some breathing difficulties occur but NOT suffocation. Research says that most CO2 gets transported as Bicarbonate.

I wish we had a medical student or something, I'm only a bachelors in science but I will do more research because you bring up an excellent point although I'm sure DR. Philip thought of all this already

 

[Sunset Limited]

Receptors in the brainstem control the CO2 and oxygen in the blood. Methemoglobin does not carry oxygen or CO2. It is CO2 receptors that control 90% of the urge to breathe but when oxygen saturation is too low, O2 receptors come into play. Tachypnea probably begins after 70% oxygen saturation.

 

[littlelady774]

No there are other ways carbon dioxide expelled. The many sn threads i read I don't remember anyone saying suffocating even survivors of sn 2019 2020.all survivors then said painless.

. Also peaceful pill has observed many sn suicides all peaceful but one a very old person. I held breath before suffocating extremely painful no sign of this kind of pain w sn

Well I don't think it would feel like suffocation though, but like fast breathing and heartrate associated with exercise.

The same thing happens when you are exercising. Lactic acid builds up in the blood because the CO2 cannot be expelled fast enough so you get fast heart rate and breathing.

 

[Jarni]

Methemoglobinemia induces dyspnea... It depends on the %...

https://www.healthline.com/health/dyspnea
Dyspnea, which some refer to as shortness of breath, is a feeling that you cannot breathe enough air into your lungs. During this, you may also experience tightness in your chest.

An Unexpected Cause of Dyspnea Caused by Dapsone-Induced Methemoglobinemia

www.ncbi.nlm.nih.gov

A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis - PubMed

Dear Editor, Dapsone is a dual-function drug with antimicrobial and antiprotozoal effects and anti-inflammatory features (1). In dermatology, it is a first choice for conditions such as leprosy, IgA pemphigus, dermatitis herpetiformis, and linear IgA bullous dermatosis, or an adjunctive...

pubmed.ncbi.nlm.nih.gov

Healthy patients with normal hemoglobin concentrations develop cyanosis at MetHb level of 15-20%, dyspnea at 20-50%, and coma at 50-70%, and die at more than 70% (2). However, patients with hematologic disease, acidosis, or cardiopulmonary diseases, for example, present with symptoms even with MetHb levels less than 15% (2,3). We inferred that our patient presented with dyspnea even under mild methemoglobinemia because he had anemia, chronic heart failure, and right pleural effusion.

 

[littlelady774]

Methemoglobinemia induces dyspnea... It depends on the %...

https://www.healthline.com/health/dyspnea
Dyspnea, which some refer to as shortness of breath, is a feeling that you cannot breathe enough air into your lungs. During this, you may also experience tightness in your chest.

An Unexpected Cause of Dyspnea Caused by Dapsone-Induced Methemoglobinemia

www.ncbi.nlm.nih.gov

A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis - PubMed

Dear Editor, Dapsone is a dual-function drug with antimicrobial and antiprotozoal effects and anti-inflammatory features (1). In dermatology, it is a first choice for conditions such as leprosy, IgA pemphigus, dermatitis herpetiformis, and linear IgA bullous dermatosis, or an adjunctive...

pubmed.ncbi.nlm.nih.gov

Healthy patients with normal hemoglobin concentrations develop cyanosis at MetHb level of 15-20%, dyspnea at 20-50%, and coma at 50-70%, and die at more than 70% (2). However, patients with hematologic disease, acidosis, or cardiopulmonary diseases, for example, present with symptoms even with MetHb levels less than 15% (2,3). We inferred that our patient presented with dyspnea even under mild methemoglobinemia because he had anemia, chronic heart failure, and right pleural effusion.

I read in healthy patients, dyspnea happens around the 50% mark, hopefully most people will be passing out by then

. Research says that most CO2 gets transported as Bicarbonate.

Most CO2 gets transported through bicarbonate ions which are in the plasma. Wouldn't methemoglobinIa change the whole blood chemistry including the bicarbonate ions in the plasma?