Discussion Medication/Substance Thread

[MatiSendiri]

Hi, I'm a pharmacy student and I'd like to answer your question about medication or substance. Ask anything really, and I answer it. I would also try as much as possible to post the source of my answer so you can explore more about that.

Why would I do this? Idk tbh. I was just bored and maybe I can help people in here. I'm also suffering from depression and still on my meds rn. There's definitely times when I feel really suicidal but situation has put me better rn.

If there's any professional here that'll notice that my answer is wrong, please correct it. I don't mind really. That's all, can't wait for your question.

 

[Freedomm]

I need to know the maximum dose of chloropyramine that suppresses the central nervous system without strong side effects. As far as I know, antihistamines in high doses suppress the vomiting center.

 

[MatiSendiri]

I need to know the maximum dose of chloropyramine that suppresses the central nervous system without strong side effects. As far as I know, antihistamines in high doses suppress the vomiting center.

This is pretty hard for me to find since chloropyramine is only used in Eastern Europe and very much easy to mistaken with chlorpheniramine in English studies. Since I can't really speak languages around Eastern Europe its pretty hard for me to get some research around chloropyramine. Here's what I found:

https://dspace.nuph.edu.ua/bitstream/123456789/11670/1/221(1).pdf

From here we found out that LD50 (lethal dose to kill at least 50% of the population) of chloropyramine is 920 mg/kg. Using this thread (https://www.bluelight.org/community/threads/how-to-translate-ld50-from-rats-mice-to-humans.923749/) we can found out that the LD50 for humans is around 74,52 mg/kg. Now is this accurate? Kinda, but you could read this paper to get more knowledge regarding LD50 in humans and rats: https://sci-hub.ru/https://doi.org/10.1177/0261192921994754

As for the side effects, here's the tricky part. We already estabilished the upper limit for you to consume by getting its LD50. But suppressing the CNS is the side effect of antihistamine. Each people have different side effects or tolerance to any of the drug, including chloropyramine. I'd suggest for you to try it yourself starting with the lowest dose possible until you found out the right dose for you to be drowsy and stop vomiting.

 

[SuicideKurt]

What drugs increase the chance of NDE at death?

 

[Fall_Apart]

I've been taking benzos for over 30 years, and for the last six, I've also been taking Lexapro. I can't reduce these medications because the withdrawal is driving me crazy. I tried doubling the Lexapro, but even then, I had a withdrawal-like crisis. The problem is that Lexapro is making me more and more like a robot, but I'm screwed now. Do you think increasing the Lexapro dose can stabilize after a period of withdrawal?

 

[cazza82]

Hi, I'm a pharmacy student and I'd like to answer your question about medication or substance. Ask anything really, and I answer it. I would also try as much as possible to post the source of my answer so you can explore more about that.

Why would I do this? Idk tbh. I was just bored and maybe I can help people in here. I'm also suffering from depression and still on my meds rn. There's definitely times when I feel really suicidal but situation has put me better rn.

If there's any professional here that'll notice that my answer is wrong, please correct it. I don't mind really. That's all, can't wait for your question.

Could the sleeping pill zopiclone work to ctb if a lot is used

 

[MatiSendiri]

What drugs increase the chance of NDE at death?

Psychedelics. Usually the stronger one will increasing the chance and effects of NDE itself. Here's a case study of a man who experience NDE with a psychedelics: https://pmc.ncbi.nlm.nih.gov/articles/PMC10345338/. There's also a study conducted towards 36 people whose ingested DMT up to a dose near the NDE: https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1532937/full#SM1.

Both of them also contain the experience of the NDE so its interesting if you want to learn more about NDE in general

I've been taking benzos for over 30 years, and for the last six, I've also been taking Lexapro. I can't reduce these medications because the withdrawal is driving me crazy. I tried doubling the Lexapro, but even then, I had a withdrawal-like crisis. The problem is that Lexapro is making me more and more like a robot, but I'm screwed now. Do you think increasing the Lexapro dose can stabilize after a period of withdrawal?

Better option is to withdraw over a long periods of time so that you can tolerate the decreasing dose tolerably. Although Lexapro (escitalopram) is a low-risk drug in terms of withdrawal, your case of withdrawal even when taking the medicine (which counted as a rebound) should be treated differently simply due to how each people will have different experience when treated with antidepressants.

Here's a study if you want to learn more about the withdrawal of antidepressants: https://pmc.ncbi.nlm.nih.gov/articles/PMC6637660/#E18

Here's a case report of tapered withdrawal of Lexapro which shows that the patient when following the withdrawal shows minimal to mild withdrawal severity: https://www.sciencedirect.com/science/article/pii/S2773021222000098

Do note that if you plan to withdraw at least talk to your doctors so they can make a plan on to your withdrawal from Lexapro.

Could the sleeping pill zopiclone work to ctb if a lot is used

Yes actually. There is a interesting report of death by zopiclone in Sweden:

Fatal Intoxications with Zopiclone—A Cause for Concern? - PMC

Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. All forensic autopsy cases ...

pmc.ncbi.nlm.nih.gov

Basically in 8 years of the study (2012-2020), there is 573 zopiclone related deaths, 354 (62%) is ruled suicide. Sadly there is no definitive report on how much is needed to ctb or how long to ctb by using zopiclone. But from that report, we can found out that zopiclone can work using alone or with other substance (the most is alcohol in the study).

Now, my motto for ctb is to be as quick and as painless as possible. Sadly though, death by medicine can be risky due to it isn't that quick to make ctb so that you can be found and still alive with organ failure. If you still consider using zopiclone, please plan your ctb as thorough as possible.

 

[SuicideKurt]

Psychedelics. Usually the stronger one will increasing the chance and effects of NDE itself. Here's a case study of a man who experience NDE with a psychedelics: https://pmc.ncbi.nlm.nih.gov/articles/PMC10345338/. There's also a study conducted towards 36 people whose ingested DMT up to a dose near the NDE: https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1532937/full#SM1.

Both of them also contain the experience of the NDE so its interesting if you want to learn more about NDE in general

Better option is to withdraw over a long periods of time so that you can tolerate the decreasing dose tolerably. Although Lexapro (escitalopram) is a low-risk drug in terms of withdrawal, your case of withdrawal even when taking the medicine (which counted as a rebound) should be treated differently simply due to how each people will have different experience when treated with antidepressants.

Here's a study if you want to learn more about the withdrawal of antidepressants: https://pmc.ncbi.nlm.nih.gov/articles/PMC6637660/#E18

Here's a case report of tapered withdrawal of Lexapro which shows that the patient when following the withdrawal shows minimal to mild withdrawal severity: https://www.sciencedirect.com/science/article/pii/S2773021222000098

Do note that if you plan to withdraw at least talk to your doctors so they can make a plan on to your withdrawal from Lexapro.

Yes actually. There is a interesting report of death by zopiclone in Sweden:

Fatal Intoxications with Zopiclone—A Cause for Concern? - PMC

Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. All forensic autopsy cases ...

pmc.ncbi.nlm.nih.gov

Basically in 8 years of the study (2012-2020), there is 573 zopiclone related deaths, 354 (62%) is ruled suicide. Sadly there is no definitive report on how much is needed to ctb or how long to ctb by using zopiclone. But from that report, we can found out that zopiclone can work using alone or with other substance (the most is alcohol in the study).

Now, my motto for ctb is to be as quick and as painless as possible. Sadly though, death by medicine can be risky due to it isn't that quick to make ctb so that you can be found and still alive with organ failure. If you still consider using zopiclone, please plan your ctb as thorough as possible.

So do I understand you correctly in order to increase my chance of NDE while CTB it's better to smoke DMT? I've heard and my personal experience was that psilocybin mushrooms deeply affected my time and one minute was feeling like one hour to me. Does that gonna make my NDE longer?

 

[MatiSendiri]

So do I understand you correctly in order to increase my chance of NDE while CTB it's better to smoke DMT? I've heard and my personal experience was that psilocybin mushrooms deeply affected my time and one minute was feeling like one hour to me. Does that gonna make my NDE longer?

I mean based on the study yeah DMT is the best option to have NDE while CTB. But then again, psychedelic experiences can vary wildly between person to person (like in the second study) so if you are comfortable with psilocybin and like its time-altering effect go ahead.

 

[Daphne]

Hi, I'm a pharmacy student and I'd like to answer your question about medication or substance. Ask anything really, and I answer it. I would also try as much as possible to post the source of my answer so you can explore more about that.

Why would I do this? Idk tbh. I was just bored and maybe I can help people in here. I'm also suffering from depression and still on my meds rn. There's definitely times when I feel really suicidal but situation has put me better rn.

If there's any professional here that'll notice that my answer is wrong, please correct it. I don't mind really. That's all, can't wait for your question.

Hello, thanks for sharing your knowledge. Do pharmacies in the US carry barbituates? What is the strongest narcotic one would find in an American pharmacy?

 

[MatiSendiri]

Hello, thanks for sharing your knowledge. Do pharmacies in the US carry barbituates? What is the strongest narcotic one would find in an American pharmacy?

I'm an Indonesian so I can't really answer that question. However, from what I can found fentanyl is still the strongest narcotics in the US pharmacy (with prescription of course):

The Most Potent (Strongest) Opioids Currently Available

Opioid use disorders still develop even under a doctor’s supervision. Read on to learn about some of the strongest opioids available today.

delphihealthgroup.com

From what I can found, barbiturates are still being sold in US pharmacy. There is no specific article about what type of barbiturates is in US pharmacy though.