LD50 dose for hydrocodone?

[rustinpeacepolaris]

i've been slowly taking some of my mother's prescription and was wondering the LD50. I dont really have a tolerance

 

[rotciv]

In rats it is 3 times greater than our Pentobarbital.

 

[cosmic_traveler]

i've been slowly taking some of my mother's prescription and was wondering the LD50. I dont really have a tolerance

Just a quick google search:

The average hydrocodone concentration in the cases where the hydrocodone caused death was 0.47 mg/L (median, 0.38 mg/L)

What is the lethal concentration of hydrocodone?: a comparison of postmortem hydrocodone concentrations in lethal and incidental intoxications - PubMed

Hydrocodone is a semisynthetic opioid medication that is widely used as an analgesic and antitussive. Since 2004 it has been the most commonly prescribed drug in the United States and is often misused as a drug of abuse. Hydrocodone is frequently encountered in the postmortem setting, both as a...

pubmed.ncbi.nlm.nih.gov

Not sure of my math but that would mean post mortem they found a total of about 20mg? Prescriptions are typically extended release formula in the 10-20mg range. We're guessing for those who've intentionally taken too much, they either crushed the pills or took more than 20 at the same time. Looking around online it looks like there's a number of cases where they took acetaminophen with their hydrocodone. Either way, surviving this kind of attempt will seriously damage your liver.

Sorry you're in so much pain. Be well on your journey.

 

[rustinpeacepolaris]

20 pills or 20mg? i'm guessing you mean 20 10mg pills. i read that article but didn't quite understand it, i have mild brain damage from a past attempt.

Just a quick google search:

What is the lethal concentration of hydrocodone?: a comparison of postmortem hydrocodone concentrations in lethal and incidental intoxications - PubMed

Hydrocodone is a semisynthetic opioid medication that is widely used as an analgesic and antitussive. Since 2004 it has been the most commonly prescribed drug in the United States and is often misused as a drug of abuse. Hydrocodone is frequently encountered in the postmortem setting, both as a...

pubmed.ncbi.nlm.nih.gov

Not sure of my math but that would mean post mortem they found a total of about 20mg? Prescriptions are typically extended release formula in the 10-20mg range. We're guessing for those who've intentionally taken too much, they either crushed the pills or took more than 20 at the same time. Looking around online it looks like there's a number of cases where they took acetaminophen with their hydrocodone. Either way, surviving this kind of attempt will seriously damage your liver.

Sorry you're in so much pain. Be well on your journey.

 

[[..redacted..]]

20 pills or 20mg? i'm guessing you mean 20 10mg pills. i read that article but didn't quite understand it, i have mild brain damage from a past attempt.

That article is talking about post mortem concentrations of the drug. It's really hard/impossible to work backwards from that to a toxic dose.

Generally hydrocodone is 2-3x less potent than morphine so you could make some rough guess based on that.

Bear in mind that it's also often combined with paracetamol - meaning a dangerous dose of hydrocodone would also involve enough paracetamol to cause severe liver damage and long term effects if you survive.

 

[rustinpeacepolaris]

That article is talking about post mortem concentrations of the drug. It's really hard/impossible to work backwards from that to a toxic dose.

Generally hydrocodone is 2-3x less potent than morphine so you could make some rough guess based on that.

Bear in mind that it's also often combined with paracetamol - meaning a dangerous dose of hydrocodone would also involve enough paracetamol to cause severe liver damage and long term effects if you survive.
interesting, thank you. and i know