everwhatever
Member
- May 15, 2018
- 25
I used ratchet, but it didn't work.ratchet was my first choice, can't manage it because of my disability though. But I think it's better than N, if you can work it.
I used ratchet, but it didn't work.ratchet was my first choice, can't manage it because of my disability though. But I think it's better than N, if you can work it.
you didn't get dizzy? how did you do it, exactly?I used ratchet, but it didn't work.
Yeah, I don't know how to say, I felt only a headache and a panic, this stuff was just disgusting for me, hanging is better I guess.you didn't get dizzy? how did you do it, exactly?
I would think that means you didn't get it high up enough on your neck. Physiologically it's very similar to hanging.Yeah, I don't know how to say, I felt only a headache and a panic, this stuff was just disgusting for me, hanging is better I guess.
Ohh this isIf you're really concerned about possible extrapyramid side effects of metoclopramide, you can take a combination of domperidone and ondansetron instead.
Metoclopramide is a D2-antagonist and 5HT3-antagonist. The EPS can occur with metoclopramide since it penetrates the blood-brain barrier. Domperidone is also a D2-antagonist but doesn't penetrate the blood-brain barrier as much, so you still get the anti-emetic effects with a much smaller risk of EPS.
Ondansetron is a 5HT3-antagonist, so taking that with domperidone is essentially the same as taking metoclopramide.
If you want to take just a single dose, you can take 40 mg domperidone and 16 mg ondansetron.
would you say ondansentron is better than the anti-emetics supplied? Or would a combination of both be optimal before the final dose?If you're really concerned about possible extrapyramid side effects of metoclopramide, you can take a combination of domperidone and ondansetron instead.
Metoclopramide is a D2-antagonist and 5HT3-antagonist. The EPS can occur with metoclopramide since it penetrates the blood-brain barrier. Domperidone is also a D2-antagonist but doesn't penetrate the blood-brain barrier as much, so you still get the anti-emetic effects with a much smaller risk of EPS.
Ondansetron is a 5HT3-antagonist, so taking that with domperidone is essentially the same as taking metoclopramide.
If you want to take just a single dose, you can take 40 mg domperidone and 16 mg ondansetron.
Ohh this is
would you say ondansentron is better than the anti-emetics supplied? Or would a combination of both be optimal before the final dose?
Is that the one from A? I actually don't know the name, that's the one I'm trying to refer to, but I'm unclear on if it's supplied really and what exactly it is. I do have some odansentran in my cabinet though so maybe I can make it useful.What do you mean by "the anti-emetics supplied?" Are you referring to metoclopramide?
Is that the one from A? I actually don't know the name, that's the one I'm trying to refer to, but I'm unclear on if it's supplied really and what exactly it is. I do have some odansentran in my cabinet though so maybe I can make it useful.
Whats a instruction? Is it 40mg meto an hr before?I know of one person who took 40mg total and did fine. They used A's instructions.