I went to the ER recently for chronic pain and they gave me nitrous oxide.
At first the strange sensation it caused was irksome/anxiety inducing, but then as it kicked in I started feeling better than I have in years.
What I realised is that I was almost entirely pain free, and the dissociative effect it caused helped me to detach from my constant thoughts of anxiety and death.
So in my own way I can relate somewhat.
I wish I lived in the states so I could get access to fentanyl. I could use it to enjoy some quality time with those I love before finally ODing and leaving this eternally painful plane.
If Fent is synthetic, then perhaps I can make it? I wonder where one would find info on that subject...