I did ketamine transfusions five years ago when my torpor, ideations, and the pain of isolation were at the worst, maybe, in all my life (including now).
It did work, but it doesn't last. I loved the high--that part was great. When I got home after the first treatment, I was euphoric, but not in a drug-hazed way (as I was while getting the transfusion--I was super high snd loved that part). When I got home, I realized, it was meme, as I know myself, but without the weight of depression and all that goes with it. Heavenly.
They make you "stack" the first couple weeks of transfusions, and I had to miss the second to last in the first two weeks. I came crashing back down, which made it all just worse. When I was able to start again, it worked, but it never lasted. The longest it ever lasted between infusions was just under three weeks, which was great, but when it wore off, it happened fast--bang, right back down.
The last time I went, which was right after the three-week stretch, I knew as soon as I got to the elevator to leave: it did nothing, but it had cost me $450. I was not willing or able to keep experimenting with it. When all was said and done, I spent almost as much as I did on a car.
There is something to it. I am certain that, at least for me, it showed that there are two different things going on: there is depression, that awful weight, and then there is suicidality. I think ketamine can probably help in the short term for suicidality.
I have a pretty low opinion of the doctors administering ketamine. The clinic I went to is part of company with about a dozen clinics in the US. They are all run by rather young psychiatrists. They make no bones about it: they are not there to work with you in the capacity of a therapist in any way, ie, not as psychiatrists. They call themselves "consultants" only. How is that ethical at all? I was left with the impression that this 30-ish-year-old "physician" had found himself a gold mine dealing ketamine legally, and I don't think he cares a bit that it doesn't last. He's making a mint, and that's what he cares about.
There is something to be learned by those who are still conducting research because it is fast acting, it does work fo both depression and SI, but it does not affect the serotonin system in the brain. If nothing else, it shows that depression and suicide affect different parts of the brain, and that depression and suicidality are neurological disorders.
Recently, this past summer, I reached a point after a lot of EMDR sessions with my current therapist that left me feeling just like I did when the ketamine had knocked out the depression and SI. It went on for quite a while, maybe a month. I was not manic, not nutty, just me, without that weight. Then I got triggered again by my very unloving family, and I crashed.
I am convinced it is neurological, and I hope that there are ethical researchers who will keep looking for answers. Ketamine is not the answer, but it was nice while it lasted. (As it should have been, for all the money I spent on it.)