I have been using opoids for many years for recreational purposes, mostly weaker ones like Kratom, Tramadol or poppy tea. I enjoy the positive effect it has on my mood, especially during winter when I can't do much outdoors. Besides I consider taking all kinds of drugs as a hobby of mine.
I haven't used O-DSMT yet, but from friends who have used it I know that it is pretty potent. So be careful not to overdose as a first time user, if you are not ready to die yet. And be sure to only use it occasionally, if you don't want to get addicted. You probably shouldn't use it more often than 2 times a month to keep the tolerance down and avoid addiction, but this also depends on the individual and dosage. As a general rule you can use the build up of tolerance to opoids as an indicator of developping a physical addiction.
Apparently rectal comsumption is a lot more effective than oral consumption. I had a friend who was addicted to O-DSMT and only did rectal consumption claiming that swallowing it is a waste of money.