Postural Tachycardia Syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in heart rate (HR) upon standing. Beta-blockade is an appealing treatment approach, but there are conflicting preliminary reports. We tested ...
www.ncbi.nlm.nih.gov
@GrizzlyGrapefruit gave me this resource. I wanted to take propanolol to reduce or prevent tachycardia as I really dislike it and it's one of the most common SN symptoms. But I haven't seen anywhere on SS when it's best to take propanolol in the method, only that it can be added. (This is not the same as taking a high dose of propanolol at the time of SN ingestion for potentiation as suggested by Nitschke.)
@GrizzlyGrapefruit commented it takes 1-4 hours for propanolol to reach its potential, and that a lower rather than higher dose is recommended, as per this study, for supine tachycardia. So I'm adding it to my method, 20 mg at the start of my 4-hour fast, 20 mg two hours in.
I will still be taking 1-2 g propanolol with the SN, but did not think it would have time to mitigate the tachycardia, and in fact propanolol OD can cause tachycardia, so it's my hope that the earlier low dose may help to mitigate this. I do not experience calming with a low dose of propanolol, so no bonus effect there.