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- May 2, 2020
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I have seen in the PPH that Propranolol should be taken with SN at the same time. But there are members here who take Propranolol an hour before drinking SN. Anyone have idea that which method is better?
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Propranolol doesn't do anything to make sn absorption more effective or faster. It is simply used to keep your heart rate more normal, that's it.
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I also wonder about the same thing.The PPH does emphasise the role of Propranolol in potentiating SN. Has that been disproven anywhere?
The PPH does emphasise the role of Propranolol in potentiating SN. Has that been disproven anywhere?
If PPH's is indeed the "better" (potentiating) option it will take 1 or 2 gm of propranolol mix with SN. (1 or 2 gm of that is not easy to acquire.) Of course my comprehension could be incorrect.Yeah, I don't know why people say propranolol is just for a calming effect. The PPH gives a pretty detailed explanation as to how the hypoxia process is sped up with a beta blocker.
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Propranolol decreases tachycardia and improves symptoms in the Postural Tachycardia Syndrome (POTS): Less is More
Postural Tachycardia Syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in heart rate (HR) upon standing. Beta-blockade is an appealing treatment approach, but there are conflicting preliminary reports. We tested ...www.ncbi.nlm.nih.gov
@GrizzlyGrapefruit gave me this resource. I wanted to take propanolol to reduce or prevent tachycardia as I really dislike it and it's one of the most common SN symptoms. But I haven't seen anywhere on SS when it's best to take propanolol in the method, only that it can be added. (This is not the same as taking a high dose of propanolol at the time of SN ingestion for potentiation as suggested by Nitschke.)
@GrizzlyGrapefruit commented it takes 1-4 hours for propanolol to reach its potential, and that a lower rather than higher dose is recommended, as per this study, for supine tachycardia. So I'm adding it to my method, 20 mg at the start of my 4-hour fast, 20 mg two hours in.
I will still be taking 1-2 g propanolol with the SN, but did not think it would have time to mitigate the tachycardia, and in fact propanolol OD can cause tachycardia, so it's my hope that the earlier low dose may help to mitigate this. I do not experience calming with a low dose of propanolol, so no bonus effect there.
@GoodPersonEffed That will be a lot of p.
Is it a lot of propranolol? I thought people with blood pressure issues take a ton more.Yes I'm aware. I've done my research, that's my choice. It is basically a dual OD of SN and propanolol.
Is it a lot of propranolol? I thought people with blood pressure issues take a ton more.
40 mg over a couple hours is a small amount.
1-2 g taken with the SN is a major amount and is not just a potentiator, but a supplemental OD. That amount can be fatal without SN, though 8 g minimum is recommended for an intentional propanolol OD, and even that can be survived, it's not a reliable method on its own because individual reactions can vary.
Ah, so are you planning on taking 1-2g? Can't high dose beta blockers bring about seizures? Scary way to OD. But yeah, if it's combination with SN, that makes sense.
Also planning on taking a high dose of diazepam for seizure prevention.
Also planning on taking a high dose of diazepam for seizure prevention.
Very interesting.
I read in PPH that propranolol induces death faster, because the lower resulting heartbeat slows down the process of reconverting methemoglobin to hemoglobin. So death occurs quicker.
About the benzo, are you going to take SN the moment you are about to fall asleep from the benzo, so that you won't experience the discomfort of the 1st 20 minutes?
Some members here secretly want their SN to mimic the peacefulness of N by timing benzos in such a way that they want to take SN after feeling super drowsy and fall asleep quickly.
The PPH does emphasise the role of Propranolol in potentiating SN. Has that been disproven anywhere?
Less pulse preventing the compensation of methemoglobin, less oxygen disposed by the brain.
Of interest, a member recently survived 2g of Propranolol, mixed with other stuff : benzo (large amount), alcohol (large), nembutal (minimal amount) and an opiod pain reliever (low amount). He reported waking up after 36 hours with pain everywhere. Wondering if it was including heart and chest discomfort, didn't dare to ask, and specifically which med, if not Propranolol, essentially caused it (so long immobility may have played a role on body parts due to blocked circulation, etc)
Just saying, if ODing on Propranolol, maybe be sure not too abort the SN with ambulance. You never know how unpleasant it will be, or can we estimate it ?
I have asthma and propanolol does exacerbate it. Also, I did a blood test with SN, put the SN directly on the open wound (don't try this), and after a few minutes I felt the SN go up my arm and down into my chest, and I began having trouble breathing. My assumption is that if I do this method, I will have trouble breathing. Shortness of breath is one of the commonly reported symptoms of SN, I made a list of symptoms and how many reported each, and trouble breathing was in around 25% of cases of those who supposedly completed ctb and reported symptoms after taking it.
Respectfully, I think this comment gets a bit off topic, though I don't think that was your intention.
Propanolol OD without SN is a different subject, it requires a minimum of 8g, and there are medical reports of survival at 12g. The person you're talking about combined different meds, no SN.
I think in your final paragraph, you were trying to show how the comment relates to this thread with regard to combining propanolol and SN and aftereffects of survival, but I didn't understand it.
It has been disproven in the PPH: 2g > 1g
Sorry, disengaging sarcasm :(
The PPH does emphasise the role of Propranolol in potentiating SN. Has that been disproven anywhere?
I'm not sure honestly. I was going based on Stan's guide. I've never heard of propranolol helping the sn method work better. Stan said it was used simply to keep the heart rate normal, for comfort reasons.The PPH does emphasise the role of Propranolol in potentiating SN. Has that been disproven anywhere?
I'm not sure honestly. I was going based on Stan's guide. I've never heard of propranolol helping the sn method work better. Stan said it was used simply to keep the heart rate normal, for comfort reasons.
I'm sorry if I was somehow incorrect. I don't have any other sources, such as the PPH.