Not all of them do but a lot of them can decrease your sexual libido. Or make it unable to get an erection. plus I've noticed than when you're depressed, sex is one of the last thing you think about. I'm in physical pain all the time so the last thing I want to do is have sex.
Have you tried Kratom? It can help with pain and depression. It didn't work for me, but I have seen reports of it being life-changing. There are scare stories about it, but you can use it sensibly to avoid tolerance by cycling it. I just wanted to mention it, just in case it can help you. I have tried a million natural remedies the past year - right now something seems to be working. I'll post my thank you to Sensei in a moment for that. I don't know if this will last, but for now it is much better.
Re sexual side effects, I tried Vortioxetine for 3 months. Not sure what if anything it did for my depression - I wanted to jump in the river and off bridges etc, constant suicidal thoughts - on the med and off it. But in terms of sexual side effects, it made it very difficult to orgasm during sex. The only way I could still orgasm and enjoy sex was by adding weed.
Weirdly, I had two weeks of happiness on a nootropic, Polygala Tenuifoila (without any meds) and during that time, the sex I had was the best I ever had. Because I have always been depressed, I had no idea how much better sex was when I was happy. It was quite amazing. Then the Polygala Tenuifoila stopped working for me.
Sigh.
I seem to be having some luck again with natural remedies though (I will go back to the dreaded meds if I have to, but am taking a break to try a few last natural remedies). I will post an update on that under Sensei's thread on natural remedies.