Method "Diphenhydramine (Benadryl) is routinely administered concomitantly with metoclopramide"

[Mofreeko]

"Diphenhydramine (Benadryl) is routinely administered concomitantly with metoclopramide or prochlorperazine to decrease the risk of a patient developing anti-dopaminergic adverse effects."

https://www.pshp.org/news/397365/Treatment-of-Acute-Migraine-Headache-in-the-Emergency-Department.htm#:~:text=Diphenhydramine%20(Benadryl%C3%A2)%20is%20routinely,developing%20anti%2Ddopaminergic%20adverse%20effects.&text=If%20the%20above%20medications%20did,other%20therapies%20could%20be%20utilized.

Thoughts?

 

[Smart No More]

I've heard people say it worked for them and others say it didn't. I hear benzos do a 'better' job of it. Generally though it seems that benadryl is given as an after thought when/if people experience such side effects. I instinctively wonder then, does it have more efficacy when administered alongside meto rather than as a remedy after the fact. Either way the anti dopaminergic side effects sound really unpleasant from the accounts I read. If you search "metoclopramide reviews" in your search engine of choice the results are plenty and whilst they're mixed there are a worrying amount that are about how terrible it made them feel and how some haven't yet recovered.

I think it's probably important to acknowledge that more people are inclined to leave reviews if their experience was bad so this can show a disproportionately biased view however the instances still exist and show the possibility is real. Albeit in perhaps lesser proportion of cases that the ratio of reviews might suggest.

I personally find it quite scary but some of that is due to the disposition my health issues put me at already.

 

[bed]

yeah dph, benzos, mirtazapine, beta-blockers, and a few other drugs are used for akathisia.
dph doesn't work for me in that regard since it gives me the paradoxical effect of RLS.