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detached

Student
Mar 31, 2019
105
I read that in the worst case you can get serious heart problems or even die.
It contains loperamide which is apparently bad for you.
What do you think?
Should I try it?
Would there be a too high risk of failing?
 
D

Donewith_

Elementalist
Sep 28, 2018
876
have just seen there is a risk of liver damage too. whats the lethal dose?
 
W

Walilamdzi

.
Mar 21, 2019
1,700
If this sort of thing was better than lethal inorganic salts, exit would be recommending them.
 
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I

Its time its time

Student
Apr 7, 2019
147
It's an OTC drug. Forget it buddy.
It's almost impossible to die from OTC drugs.

Most prob you'll end up vomitting out the drugs.
And suffering lots/ fucking up your body.
 
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D

detached

Student
Mar 31, 2019
105
have just seen there is a risk of liver damage too. whats the lethal dose?
I'm not sure. I'm guessing its really high since otc drugs usually aren't dangerous in low doses.
have just seen there is a risk of liver damage too. whats the lethal dose?
"When people have suffered an Imodium overdose, they've often been taking an average of 250 a day, although an overdose can occur when someone is taking less than this."
I read it on https://www.therecoveryvillage.com/loperamide-abuse/loperamide-overdose-death/#gref
 
Last edited:
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chrijo

chrijo

done
Feb 8, 2019
329
I read that in the worst case you can get serious heart problems or even die.
It contains loperamide which is apparently bad for you.
What do you think?
Should I try it?
Would there be a too high risk of failing?
Loperamide is a very strong opioid but it can not cross the blood brain barrier ( = otc). But there are some drugs that make that possible.

Verapamil or Chinin for example. Both are P-glycoprotein inhibitors. Ask google if you want to know more about it, especially about his function at the blood brain barrier.

If loperamide gets into your brain, you'll have the same effects as fentanyl. Don't play around with it :-)
 
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J

J F

Member
Aug 17, 2018
79
Wait verapamil is a potentiator of loperamide and/or allows it to cross the bb barrier? I didn't know. When you say it has the same effects as fentanyl I am not sure what you mean. Pardon my ignorance. I know fentanyl has a high rating in the recent Ppeh for an end of life agent. It has a really high score for peacefulness and reliability.

So...if we can make loperamide have the same effect on the brain as fentanyl does that mean it's just as peaceful and reliable as fentanyl? Or am I way off base here and don't know wtf I am talking about.

I live in Canada. Fentanyl is next to impossible to get now. But both loperamide (otc that's why) and verapamil are not,
 
Kikoo Loool

Kikoo Loool

Enlightened
Feb 25, 2019
1,128
Sorry guy: otc pills aren't suitable to ctbn they just cause damage to liver and kidney and can be very painful but won't achieve your goal.
 
J

J F

Member
Aug 17, 2018
79
Loperamide is a very strong opioid but it can not cross the blood brain barrier ( = otc). But there are some drugs that make that possible.

Verapamil or Chinin for example. Both are P-glycoprotein inhibitors. Ask google if you want to know more about it, especially about his function at the blood brain barrier.

If loperamide gets into your brain, you'll have the same effects as fentanyl. Don't play around with it :-)
Sorry to keep harping in this. But I just found this site on loperamide and it's dangerous effects as a result of various drug interactions. Had no idea it can be this dangerous.

.
 
chrijo

chrijo

done
Feb 8, 2019
329
Loperamide is absolutely harmless in itself because it cannot cross the blood brain barrier like other opioids. The P-glycoprotein prevents the permeability for loperamide. This means, you'll need an P-glycoprotein inhibitor like verapamil.

Fun-Fact: Babies do not have a fully functional blood brain barrier. If you give a baby loperamide, it's probably gonna die from an opioid overdose.
 
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Macc Lad

Macc Lad

Specialist
Jan 22, 2019
300
I read that in the worst case you can get serious heart problems or even die.
It contains loperamide which is apparently bad for you.
What do you think?
Should I try it?
Would there be a too high risk of failing?

jesus wept !!! the only thing that will happen is that you will not go for a dump for about 6 weeks !!!!
 
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J

J F

Member
Aug 17, 2018
79
Loperamide is absolutely harmless in itself because it cannot cross the blood brain barrier like other opioids. The P-glycoprotein prevents the permeability for loperamide. This means, you'll need an P-glycoprotein inhibitor like verapamil.

Fun-Fact: Babies do not have a fully functional blood brain barrier. If you give a baby loperamide, it's probably gonna die from an opioid overdose.
This clarifies it thx. You said to stay away from the stuff in a previous post above. Is it because it's a pretty painful way to ctb or an ineffective way? Or a very effective but painful way? I already got verapamil. Very easy to get loperamide here in Canada.
 
chrijo

chrijo

done
Feb 8, 2019
329
You're gonna get a typical opioid overdose, you're going to fall asleep and stop breathing. No pain, but you're very likely to vomit.

In various drug forums it has already been experimented with. Maybe you can learn more about it there. I'm a theory guy :-)
 
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J

J F

Member
Aug 17, 2018
79
You're gonna get a typical opioid overdose, you're going to fall asleep and stop breathing. No pain, but you're very likely to vomit.

In various drug forums it has already been experimented with. Maybe you can learn more about it there. I'm a theory guy :-)
Do you think it's a good idea to take Metoclopramide with it?

Sorry to keep harping in this. I am looking for a plan b in case my first ctb method fails. I am strongly considering this to be my plan b: loperamide with verapamil and a strong anti-emetic.
 
chrijo

chrijo

done
Feb 8, 2019
329
Opioid vomiting is mainly caused by dopamine., so yes, meto is your first choice.

Be careful with that and read reports in some drug forums. If you can get the loperamide in your brain, you won't be able to control it.
 
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pinkblanket55

pinkblanket55

Member
Mar 14, 2019
76
Very, very unlikely to die from loperamide overdose and if you did it wouldnt be quick and painless.. Only attempt to ctb by drug overdose with regimens proven to work. Pph has quite a few options.
 
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L

Lifeisatrap

Arcanist
Oct 5, 2018
408
Just came across this thread to get more info on imodium. Since I was thinking of using it to wash down some xanax+a couple of benydryl along with some tylenol pm right before taking sn. Is that a good idea or would it cause a higher likelyhood of failure? Really wish I was a doctor so this would be easier. Will be taking zofran an hour before and cimetidine 30 mins before.
 
F

fister

Member
Apr 11, 2019
95
Just came across this thread to get more info on imodium. Since I was thinking of using it to wash down some xanax+a couple of benydryl along with some tylenol pm right before taking sn. Is that a good idea or would it cause a higher likelyhood of failure? Really wish I was a doctor so this would be easier. Will be taking zofran an hour before and cimetidine 30 mins before.
On YouTube a user called ChubbyEmu summarized a case study of a straight loperamide overdose.
 
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Lifeisatrap

Arcanist
Oct 5, 2018
408
On YouTube a user called ChubbyEmu summarized a case study of a straight loperamide overdose.
I was trying to go over my plans to see if anyone had any suggestions on how to make it more fail safe or if it sounds good as is? Besides other antiemtics which I can't get a hold of. Can't afford another failure since I've already landed in mental hospital 3 times. Any thoughts or suggestions would be of great help.
 

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