Cant take meto, no domperidone, what else can I take as an antiemetic before n..

[bubbletea]

Can't take meto because of past benzo use. I still get jerks and spasms for no reason .. it gets worse when I drink alcohol or even take magnesium.. I really have to take n soon but now I'm worried about throwing up.

 

[311]

Why cant u take meto

 

[bubbletea]

I'll quote @cantstandanymore

• #2

Yes. Take Domperidone instead. It doesn't cross blood brain barrier.

EPS symptoms are caused by excess blocking of dopamine receptors. Gaba opposes dopamine at most of the time, as it's an inhibitory neurotransmitter afaik. You maybe disturbed your excitatory signal-inhibitory signal balance by long term benzo usage.

GABA receptor agonists display a dual action on DA-mediated events. One includes a decrease in DA release, reduction in DA receptor density, and decreased response of postsynaptic cells to dopaminergic stimulation; it results in antidopaminergic effects

@Can'tStandAnymore

 

[311]

Did you get symptoms from it?

 

[chrijo]

How long did you use benzos? Alcohol, benzos and barbiturates have a significant cross-tolerance.

if you're a benzo addict, you have increased susceptibility to convulsions. Metoclopramide intensifies the symptoms.

Use domperidone...it doesn't have those side effects.

 

[311]

How long did you use benzos? Alcohol, benzos and barbiturates have a significant cross-tolerance.

if you're a benzo addict, you have increased susceptibility to convulsions. Metoclopramide intensifies the symptoms.

Use domperidone...it doesn't have those side effects.

Pph and all suicide books reccomend meto

 

[bubbletea]

How long did you use benzos? Alcohol, benzos and barbiturates have a significant cross-tolerance.

if you're a benzo addict, you have increased susceptibility to convulsions. Metoclopramide intensifies the symptoms.

Use domperidone...it doesn't have those side effects.

For three years while I was also an alcoholic. Domperidone is hard to find.. is there a link..

 

[311]

For three years while I was also an alcoholic. Domperidone is hard to find.. is there a link..

Honestly 12g of nembutal should be fine. Where are you located. Message me at @mokota
On telegram

 

[chrijo]

Pph and all suicide books reccomend meto

I know. Metoclopramid has side-effects and some people are sensitive to it. This reaction has a name: Extrapyramidal symptoms.

...and if you have extrapyramidal symptoms, look for alternatives and never OD metoclopramide, take a maximum of 10mg at once and 30mg/day. Some people can't handle the recommended stat-dose from PPH.

 

[BellaKAT]

In theory if a small female took 30 mg over the course of 24 hours could that be enough meto to be a sufficient antiemetic? I'm thinking of trying this Thursday if I still haven't got tracking updates from my domperidone order.

 

[bubbletea]

In theory if a small female took 30 mg over the course of 24 hours could that be enough meto to be a sufficient antiemetic? I'm thinking of trying this Thursday if I still haven't got tracking updates from my domperidone order.

Where did you order it?

Honestly 12g of nembutal should be fine. Where are you located. Message me at @mokota
On telegram

Yes but theres the concern of keeping it down.

I know. Metoclopramid has side-effects and some people are sensitive to it. This reaction has a name: Extrapyramidal symptoms.

...and if you have extrapyramidal symptoms, look for alternatives and never OD metoclopramide, take a maximum of 10mg at once and 30mg/day. Some people can't handle the recommended stat-dose from PPH.

Domperidone doesnt induce side effects?

 

[311]

I know. Metoclopramid has side-effects and some people are sensitive to it. This reaction has a name: Extrapyramidal symptoms.

...and if you have extrapyramidal symptoms, look for alternatives and never OD metoclopramide, take a maximum of 10mg at once and 30mg/day. Some people can't handle the recommended stat-dose from PPH.

Just do a smaller amount of it.. or you will u vomit

 

[chrijo]

In theory if a small female took 30 mg over the course of 24 hours could that be enough meto to be a sufficient antiemetic? I'm thinking of trying this Thursday if I still haven't got tracking updates from my domperidone order.

Hi BellaKat :-)

In germany they took the high-dose meto off the market precisely because of these side effects. If you want to try it again, take 10mg every 8 hours. An overdose doesn't make the antiemetic potential more effective. Antiemetics only lower the probability, but they're not a guarantee.

Domperidone doesnt induce side effects?

Domperidon does not pass the blood-brain-barrier, that prevents extrapyramidal symptoms.

 

[311]

extrapyramidal symptoms are caused by the dopamine antagonist effects not the blood barrier try smaller doses of meto over.a week till you are ready

 

[chrijo]

Hi @311,

The cause of this bad reaction is behind the blood brain barrier if any dopamin-antagonist blocks d2-receptors in the central nervous system. Domperidone can not pass the barrier and therefore cannot block anything in the cns.

I know that topic is very complex, excuse my unnecessarily complicated writing..