Amitriptyline alone causes deep coma, or are benzos essential?

[dmtz]

I think the advice to always take benzos with tricyclic may be unnecesary...what do you think?

My issue is I've been taking benzos for more than 5 years, so I'm tolerant to them.

BUT IMPORTANTLY everything I research using chatgpt premium indicates that amitriptyline in overdose of several grams causes always a deep coma before 6 hours

There could be seizures before that, but I've had seizures before and one feels nothing bad...also high temperature

Anyway I would also take massive dose of benzos, just that I don't think they'd do much give my tolerance

 

[Michi_Violeta]

I'm curious about this as well because I'm planning on either chloroquine/amitriptyline or a mix of both per the PPH. From what I understood, the benzos are recommended so you can die in your sleep before either the amitriptyline or the chloroquine cause cardiac arrest. The amitriptyline, oddly enough, is supposed to have a sedative effect to so I can imagine that 10 grams or so of the stuff should knock you out, but it's very hard finding information on the matter and I can't ask GPT Premium.

Have you considered maybe another sedative as an alternative?

 

[dmtz]

Clonidine in massive overdose seems to induce a longlasting coma, maybe could theoretically use that instead