Yeah a beta blocker isn't beneficial for the method. I saw someone who mentioned POTS too, beta blockers aren't helpful with POTS because they attack tachycardia directly. It's a little more complicated than that. Many people somewhat irrationally have a fixation about tachycardia that makes them anxious and makes the tachycardia even worse, so it's not all in their heads, but their heads make it worse. Once you get into the upper echelons of heart rate the heart can no longer fill the atria with blood quickly enough during diastole and the volumetric efficiency decreases, so you're pumping less blood at the highest heart rates, and at some point the heart tissue isn't being perfused as well with oxygen and the byproducts of anaerobic respiration aren't being removed efficiently so you start to feel chest pain. It's not an infarct but more like a muscle ache or feeling the burn when working out. The beta blockers also help with the anxiety especially when they're non cardioselective. With POTS it's physiologically counterproductive to always be trying to turn down the heart rate because your heart rate is increased due to a physiological need for more oxygen, and if your heart rate isn't always at a sky high extreme, you're effectively forcing your system into getting even less oxygen by hamstringing the heart. The beta blocker as a whole ends up limiting your physical ability to compensate. There is a better med choice, ivabradine, which has effects that work in increasing the volumetric efficiency of each beat. Hyperadrenergic pots is quite distinct from the other types when it's properly diagnosed, and it often isn't properly diagnosed. Hyperadrenergic pots is quite similar to a pheochromocytoma, especially the level of norepinephrine, except that the Hyperadrenergic states primarily exist while orthostatic rather than while supine.