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Placo
Life and Death
- Feb 14, 2024
- 707
In this thread I will talk about my therapies and general experiences with substances, I could also go into detail explaining the various neurotransmitters and receptors and how these influence various mental pathologies.
I'll start by saying that my main problems are depression, anxiety and OCD, a combination that I've read already has a very high suicide rate, so the mere fact that I'm writing this thread at 30 is a victory or at least a good test of endurance, I don't know if I have other disorders but I don't think so.
Here is my current therapy:
40mg paroxetine
30mg mirtazapine
37mg lurasidone
15 drops of diazepam as needed
As a therapy, however, it seems weak on the motivational aspect which is regulated more by dopamine while these drugs have little dopaminergic activity and in fact lurasidone is a partial antagonist of some dopaminergic receptors and therefore I decided on my own initiative to add bupropion which is an NDRI to the therapy, tomorrow I will discuss it with the psychiatrist and see his opinion.
Also as for benzodiazepines I go well beyond 15 drops and use more than one and to calm myself I also help myself with alcohol and nicotine.
With bupropion I usually take 150mg but on days when I'm sleepy I can even take 300mg, I also help myself stimulate myself with caffeine obviously, but I was considering that to stay awake modafinil is more suitable than bupropion, maybe I'll suggest it to the psychiatrist or buy it online, maybe taking both won't hurt since I need both to stay awake on days when I'm sleepy and the activation that bupropion gives.
Having used SSRIs for a long time makes me quite familiar with the effect that excess serotonin has on me, it tends to lift my mood even if it doesn't encourage motivation, in fact some hypothesize that SSRIs can cause amotivational syndrome, the downside however is a greater predisposition to anxiety.
I can also say that a general increase in dopamine in neurotransmission has effects on me, it increases motivation but also paranoia and could also increase OCD, in fact lurasidone fights OCD by antagonizing some dopamine receptors while it is a partial agonist on some serotoninergic receptors, in theory it should have both an anti-obsessive and anti-depressant effect. At 18.5mg the effect seems to be antidepressant even if lately I have gone up to 37mg where it seems that the sedation is starting to take over.
As for norepinephrine I'm a little less sure of the effects it has on me although I hypothesize greater activation and anxiety, I think I mirror the effects it has on the majority of the population.
If you want to add any comments, please do so.
I'll start by saying that my main problems are depression, anxiety and OCD, a combination that I've read already has a very high suicide rate, so the mere fact that I'm writing this thread at 30 is a victory or at least a good test of endurance, I don't know if I have other disorders but I don't think so.
Here is my current therapy:
40mg paroxetine
30mg mirtazapine
37mg lurasidone
15 drops of diazepam as needed
As a therapy, however, it seems weak on the motivational aspect which is regulated more by dopamine while these drugs have little dopaminergic activity and in fact lurasidone is a partial antagonist of some dopaminergic receptors and therefore I decided on my own initiative to add bupropion which is an NDRI to the therapy, tomorrow I will discuss it with the psychiatrist and see his opinion.
Also as for benzodiazepines I go well beyond 15 drops and use more than one and to calm myself I also help myself with alcohol and nicotine.
With bupropion I usually take 150mg but on days when I'm sleepy I can even take 300mg, I also help myself stimulate myself with caffeine obviously, but I was considering that to stay awake modafinil is more suitable than bupropion, maybe I'll suggest it to the psychiatrist or buy it online, maybe taking both won't hurt since I need both to stay awake on days when I'm sleepy and the activation that bupropion gives.
Having used SSRIs for a long time makes me quite familiar with the effect that excess serotonin has on me, it tends to lift my mood even if it doesn't encourage motivation, in fact some hypothesize that SSRIs can cause amotivational syndrome, the downside however is a greater predisposition to anxiety.
I can also say that a general increase in dopamine in neurotransmission has effects on me, it increases motivation but also paranoia and could also increase OCD, in fact lurasidone fights OCD by antagonizing some dopamine receptors while it is a partial agonist on some serotoninergic receptors, in theory it should have both an anti-obsessive and anti-depressant effect. At 18.5mg the effect seems to be antidepressant even if lately I have gone up to 37mg where it seems that the sedation is starting to take over.
As for norepinephrine I'm a little less sure of the effects it has on me although I hypothesize greater activation and anxiety, I think I mirror the effects it has on the majority of the population.
If you want to add any comments, please do so.