I've now been taking Venlafaxine for nearly 8 months. I take 375mg a day - 225mg in the am and 150mg in the pm.
So far, I've not had many side effects that I've been conscious of. There've been two that have been more obvious, however:
1) Sleep Quality for me has decreased pretty significantly. I'm more tired, more often. Doesn't mean I'm less effective in work or anything, and there's even a possibility that it's not related to the Venlafaxine but it seems too coincidental to not be related.
2) I think the technical term is sexual dysfunction - but I basically have trouble popping the cork. Might sound like a blessing, but sometimes it can be pretty annoying and it doesn't exactly flatter my partner.
Another issue is as other people have commented: the withdrawal/short half life. I take my total dose in two because I feel a little "high" if I take it all in one go, but if I miss one I really feel off. I've never missed more than a half-days dose and based on what I've read about in both scientific literature and accounts like some users have written about and I'm very worried about coming off them.
I'm more than happy to cross that bridge when I come to it, as I haven't felt this
consistent in a long time. I'm still a miserable twat and still get angry at stupidly small things, but I'm still here and there's a strong chance I wouldn't be without it, amongst others.