SN method- antacids

[UnlockTheShrine]

Is it really needed to use antacids like Tagamet or Ranitidine? It should sped up the absorption of SN, but I've read that it delays the loss of consciousness.
Shouldn't just fasting suffice?

 

[spanishguy22]

I've wondered the same but it seems successful ctb has been done with antiacids mostly, so I'd takr them

 

[Vegrau]

Cimetidine IS NOT antacid. Antacid will reduce the efficacy of cimetidine.

What’s the difference between cimetidine and an antacid? | Antacid

Cimetidine is in a group of medications called histamine type-2-receptor antagonists that block the release of histamine which triggers the secretion

www.sharecare.com

Effects on cimetidine bioavailability of metoclopramide and antacids given two hours apart - PubMed

Plasma cimetidine levels were determined in 9 normal subjects after a single oral dose of cimetidine 400 mg under control conditions, 2 h before metoclopramide 20 mg and 2 h after a potent antacid. The bioavailability of cimetidine was not significantly affected by metoclopramide and it was...

www.ncbi.nlm.nih.gov

 

[UnlockTheShrine]

Cimetidine IS NOT antacid. Antacid will reduce the efficacy of cimetidine.

What’s the difference between cimetidine and an antacid? | Antacid

Cimetidine is in a group of medications called histamine type-2-receptor antagonists that block the release of histamine which triggers the secretion

www.sharecare.com

Effects on cimetidine bioavailability of metoclopramide and antacids given two hours apart - PubMed

Plasma cimetidine levels were determined in 9 normal subjects after a single oral dose of cimetidine 400 mg under control conditions, 2 h before metoclopramide 20 mg and 2 h after a potent antacid. The bioavailability of cimetidine was not significantly affected by metoclopramide and it was...

www.ncbi.nlm.nih.gov

Same goes for Ranitidine? So they don't delay the loss of consciousness?

 

[Vegrau]

Same goes for Ranitidine? So they don't delay the loss of consciousness?

No it shouldnt. Cime have a side effect of making you drowsy. Unless drowsy actually make you harder to fall asleep???

 

[spanishguy22]

I know PPIs should not be used because they keep you from unconciousness by keeping Blood pressure from going down by SN, but idk why antiacids delay it, by which mechanism.

 

[Vegrau]

I know PPIs should not be used because they keep you from unconciousness by keeping Blood pressure from going down by SN, but idk why antiacids delay it, by which mechanism.

We fall unconscious because of Hypoxia not because of lower blood pressure. As far as I know.

 

[spanishguy22]

We fall unconscious because of Hypoxia not because of lower blood pressure. As far as I know.

there may be more than one avenue
this is one of the posts

Do not take any proton pump inhibitor (PPI) with SN! That is, NO omeprazole, esomeprazole, pantoprazole or any other -prazole drug. The blood pressure-lowering effect of ingested SN is blocked by pretreatment with a PPI. Moreover, it is advised to stay away from these drugs for at least 2 weeks before the SN attempt.

You may take ranitidine or famotidine if they are available in your country. There is no cimetidine either where I'm from.

 

[Vegrau]

there may be more than one avenue
this is one of the posts

Well we will be using cime anyway so we pretty much sidestep the whole thing. Oh and just you know the meto might actually increase blood pressure. So yeah I am not counting on blood pressure.

 

[spanishguy22]

Well we will be using cime anyway so we pretty much sidestep the whole thing. Oh and just you know the meto might actually increase blood pressure. So yeah I am not counting on blood pressure.

thats nothing in comparison to the blood pressure reduction SN makes though.

 

[Vegrau]

thats nothing in comparison to the blood pressure reduction SN makes though.

Well just pointing it out. If meto is incapable of disrupting the SN blood pressure lowering properties. What can antacid do? Unless it completely block our body from absorbing SN. Or else it doesnt make sense. You do know SN affect blood directly. So how can it give us hypoxia while unable to lower the blood pressure if SN already inside our blood? Well like I said before we will be using cime. This is hardly a problem. Using antacid lower the efficacy of cime. Thats the main reason why we shouldn't use antacid.

 

[spanishguy22]

Well just pointing it out. If meto is incapable of disrupting the SN blood pressure lowering properties. What can antacid do to raise it?

i never said antiacids raise bp, but that PPIs keep it from lowering it.
idk abut how antiacids delay unconsciousness

 

[Vegrau]

i never said antiacids raise bp, but that PPIs keep it from lowering it.
idk abut how antiacids delay unconsciousness

Read again, I edited my post already. Before I even saw your post. I didnt meant to say antacid raise blood pressure. Dont dwell or hankering over a typo.

Also PPI actually lower blood pressure. Take it what you will.

Because they equate lower blood pressure to being easier to get unconscious.

(PDF) Proton-Pump Inhibitors Therapy and Blood Pressure Control

PDF | Objective: To evaluate the potential impact of inhibitors of proton-pump in blood-pressure. .Methods: In a 24-hour-ambulatory-blood-pressure-monitoring (AMBP)-database we analyzed records of 462-hypertensive-patients according Proton-Pump Inhibitors (PPI). 150(33%)-patients...

www.researchgate.net

Commentary on “The blood pressure-lowering effect of orally ingested nitrite is abolished by a proton pump inhibitor” by M. F. Montenegro et al

www.ncbi.nlm.nih.gov

I think these should make my doubt clear enough.