I can't get my hands on metaclopromide and in any state it makes me very sleepy, I have quitiapine and I'm also on mitrazipine at night which my psychiatrist told me is a great anti nausea. How much quitiapine would I need for a stat dose? I'm already taking 100mg at night. Also with the antacid can regular quickeez work as I have no way of getting milk of magnesia. Otherwise my husband has ondansatron.
BizarreBazaar
Student
- Feb 26, 2020
- 104
There is no stat dose for quetiapine and other antipsychotics. If I understand correctly, you only need to take them daily and have enough in your system to act effectively.
BizarreBazaar
Student
- Feb 26, 2020
- 104
autumnal
Enlightened
- Feb 4, 2020
- 1,950
For my opinion on this question, review this thread and all of the quoted discussion within it in its entirety.
Further to that thread, the consensus here is that you definitely cannot use a stat does of Quetapine for antimetic effects. You need to be taking it regularly to build up amounts in the body.
Instructions for gradually titrating (adjusting) your dosage to increase to a higher one are here.
Oh sorry I hadn't seen that. I wouldn't be able to build up to that over the week as my husband does all my meds. Hmmm what to do? Will being on 100mg at least do something? Like I say I'm also on mitrazipine.
autumnal
Enlightened
- Feb 4, 2020
- 1,950
Opinions on the forum will differ widely and strongly on this. But my own opinion, as supported by the reference quoted in my thread, is that 100mg of Quetapine will not have the desired antiemetic effect. As the reference describes the pharmacological profile of Quetapine as varying by dose, 100mg won't even have a mild antiemetic effect (nor one-third of the antiemetic effect of 300mg) as that 100mg dosage simply does not target the relevant neuroreceptors.
Although an antidepressant, Mitrazapine does also have some off-label use for nausea and vomiting. However, it targets the 5-HT3 brain receptors only. Metoclopramide is recommended for the SN method as it targets the D2 receptors. However, it would take someone with more psychopharmacology knowledge than me to advise whether Mitrazapine is as effective as Metoclopramide (or even remotely effective) based upon this targeted receptor difference.
Quarky00
Enlightened
- Dec 17, 2019
- 1,956
Yes , members have ctbed with SN on that dosage . We can't know for sure but it appears to be okay/helpful as AE .
@autumnal and I disagree about that conclusion (stated above) , I totally respect their position , and I admire the honest way they presented it. Otherwise there is no stat dose for that , as mentioned . For those unable to use metoclopramide there are other options , such as domperidone . If you can't use meto/domp , then use what you have . It should depress vomiting to some extent , and in any way (even if vomit) SN is fatal .
FAQ - Antiemetics
(If you want to read more)
autumnal
Enlightened
- Feb 4, 2020
- 1,950
For users who aren't familiar with the scientific method, it's worth pointing out the following. Successful attempts without any nausea or vomiting using 'low' (less than 300mg) doses of Quetapine are not neccesarily evidence that low doses actually have an antiemetic effect.
The likelihood of any person having nausea with SN depends on a whole range of factors, including SN dosage, stomach emptiness, gastric acidity, weight and the ever-present individual differences. People who took low doses and had no nausea might not have had any nausea even without Quetapine. The absence of any kind of controlled experiments on this topic (for obvious moral reasons) means that the only semi-definitive information which exists is that resource I have listed. It's certainly not what I would call a mass of supporting evidence, but so far it is all there is.
Successgul accounts of users taking low doses of Quetapine should therefore be regarded with a healthy skepticism. Because of the lack of definitive information on this topic, you may choose to place weight on these success accounts, especially if there are a large enough number of them to make you believe they are not purely coincidental. You may even decide these accounts are more credible than the resourced I listed. But just understand the limitations inherent in depending on them when making your final decision. In the end, it's you who will experience the unpleasantness of nausea, vomitting and even possible failure from possibly not taking an effective antiemetic.
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