hey there, i've done way too many psychedelics in my life and here's my experience doing them primarily by myself as a depressed person:
even nowadays i'll experience some sort of anxiety spike while on psychs but in my experience, researching and studying a trip report or the effects on whatever psychedelic you do can help you ground yourself and relax while on it. i find the experience alot less worrisome when you do alot of research (while sober ofc) and as someone who does psychs alone 95% of the time it's helped me greatly when it comes to controlling yourself.
of course if you can get one, always have a trusted person to be a trip sitter for you in case you need anything. if you can't find one i would say prepare things you'll need beforehand and keep them in arms reach (water, snacks, activities, etc).. something i find that helps me is timing the trip on a watch, i'm not sure if it affects your perception or whatever but for me being able to check into the real world and see how long i've been tripping helps remind me that: i'm on drugs and that after a certain amount of time IT DOES END and doing this has made my trips feel alot more under control
other than that i would say to remind yourself to let go and not fight the experience in order to have a comfortable time. the trip does come to an end even if you're having a bad one fortunately so just hold on tight and drink water if you're feeling off. i recommend listening to calming or fun music to help yourself along
this is all just my experience though, bottom line is do your research and remember that you're on drugs. i feel like people can freak out when they forget that they just took drugs. i try to see it as a quick vacation to another planet. i tripped for the first time at night in my bedroom alone when i was 17, i survived and enjoyed it! but only you know yourself so if you feel fearful of doing them, i think it's best to not do them until you feel ready.
source: people ask me to tripsit them, this is what i tell them. i've done shrooms, acid, molly, 2cb. my favorite is lsd and i've been doing psychs for 5+ years, i hope this helps!