A

Arak

Enlightened
Sep 21, 2018
1,176
Recently there had been a skirmish in a thread, which prompted me to ask staff the close the thread. Someone did make a good point though.

Originally pentobarbital was not my method of choice. I was upset when I learned that exsanguination just does not work, some lethal drugs like cyanide were no longer available at all. The modern world and its incoveniences. There were many considerations, at some point (mid 2018 ?) I tried to obtain sodium azide only to learn that the REACH guidelines had made it completely unavailable. Even a seller in Poland would not respond by email.Now, it may be I recently did find a seller who would sell me sodium azide. Currently it's out of stock. Even so, it's extremely brutal and I would rather avoid that gruesome fate. You really need some balls.

At some point I allowed my doubts to be 'put at ease' and for lack of availability of anything else, I decided to pursue Nembutal. I just received it very, very late.

Now I have a full 13 gr of Nembutal at hand. With the promise of a soft death. Possibly, gruesome alternatives like sodium azide. The temptation of N over SA, right ?

Obviously, I'd prefer a soft death. But the comment that an altered central nervous system, heavy tolerance to or dependence on sedatives (CNS depressants) can change things, to an extent that you may not be able to overcome this by increasing the dose made sense. After all, the way pentobarbital mainly exerts its lethal influence is by hypoxia. Which is mostly caused by its effect on the brain stem. I know the theory, there is definitely cross tolerance with benzodiazepines but also other sedatives. It came to my attention that there may be a very real chance of surviving N, but with brain damage or other organ damage.

We have to keep in mind that many of those suicide books have been written by doctors. Some advise tapering off drugs like benzodiazepines prior to the deed. Unlike many other people, I did not have an ethical doctors but suffered severe iatrogenic damage caused by medical errors, in somatic healthcare. I'll skip the specifics. They really messed me up. As far as drugs go, not just a simple sleeping pill because I asked for it ... It usually gets worse when doctors do that sort of thing.
I certainly don't have that rosy picture of doctors that some people have. I'm not one of those people who have been treated so well as the people who got treatment by the Dutch and Swiss Euthanasia/assisted suicide services.

The pentobarbital is at hand. Duration of action about 1-2 hours. If it doesn't kill me there may be very unpleasant consequences. In a previous thread someone suggested Dilantin (also mentioned by Nitschke?) but that itself could be very brutal if the pentobarbital doesn't work properly, it's not an analgesic.

Ideas about anything to add to the pentobarbital method ? I know the other method threads, obviously.
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
May I ask which country you are in and whether you have considered Fentanyl as an add-on? Or something like Quetiapine.
 
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A

Arak

Enlightened
Sep 21, 2018
1,176
A country in Europe that I'd rather not mention (not UK). Fentanyl also acts on the brain stem but at different receptors, I will likely have at least some (cross) tolerance with opiates.I may know a source for 100 mcg patches, 800 mcg sublingual tablets but especially the latter at a (very) high cost.
I'm just not sure how quetiapine would help.
 
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Sinbad

Sinbad

Self-Annihilation is loading...95%
Nov 27, 2018
542
Arak, 13 g will kill you. Don't worry. Drink some alcohol after drinking N in order to heighten the effect.
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
I have heard people mention they are thinking of combining Fentanyl and Nembutal for added "certainty" as it were. With regard to the quetiapine, I was just curious as to whether is was worth further investigation as people have mentioned it having such a deep sedative effect on them where benzodiazepines have not affected them. It made me wonder why.
 
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therhydler

therhydler

Enlightened
Dec 7, 2018
1,196
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
Wait why quetiapine?

It has occasionally been prescribed off-label for insomnia. I've been offered everything to try and make me sleep!
 
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therhydler

therhydler

Enlightened
Dec 7, 2018
1,196
It has occasionally been prescribed off-label for insomnia. I've been offered everything to try and make me sleep!

I've been on quetiapine for like 3 months. Can't sleep without it. But isn't it also an antipsychotic? And those can have a negative effect on N if used for a prolonged period... so I'm a bit worried... is 3 months prolonged?
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
I've been on it for like 3 months. Can't sleep without it. But isn't it also an antipsychotic? And those can have a negative effect on N if used for a prolonged period... so I'm a bit worried... is 3 months prolonged?

Yes, it's also an anti-psychotic. I think it can be offered for different things depending on dosage. Have a read up and see what you can find out xx I know very little - only that I keep getting offered everything under the sun to make me sleep and I get the information leaflets in the medication packets
 
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color_me_gone

color_me_gone

Sun is rising
Dec 27, 2018
970
Arak, the things you speak of are exactly the reason drugs are not my method of choice. Too many variables enter into the equation, some cases excruciating painful death, high failure rate, screwed up organs. But of all meds, N seems the most promising, and would be my choice if there were no other options.
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
I've been on quetiapine for like 3 months. Can't sleep without it. But isn't it also an antipsychotic? And those can have a negative effect on N if used for a prolonged period... so I'm a bit worried... is 3 months prolonged?

I think @Passingby has good advice above for when you are ready eg test the 5ml and see x
 
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therhydler

therhydler

Enlightened
Dec 7, 2018
1,196
But is there an actual risk of surviving with brain/organ damage? Isn't it just a risk of entering a coma before you die? I don't mind being in a coma as long as im dead at the end and don't regain consciousness
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
But is there an actual risk of surviving with brain/organ damage? Isn't it just a risk of entering a coma before you die? I don't mind being in a coma as long as im dead at the end and don't regain consciousness

Just been trying to find the piece I read earlier (if anyone else finds it pls post it) it has timings on about how long to pass after consuming N.
 
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color_me_gone

color_me_gone

Sun is rising
Dec 27, 2018
970
Passingby Thanks for that link! I have found that wikibook series to have a lot of very good information, facts and history. It is a very useful tool for the people of this community. I wonder if it is listed in the reference section? If not, it should be.
 
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Deleted member 4993

Guest
Suicide/Toxification/Antiemetic regimen - Wikibooks, open books for an open world
The human body employs several distinct mechanisms to trigger vomiting in response to different stimuli. It follows that there is no universal antiemetic that would prevent vomiting irrespective of the cause; indeed, each particular antiemetic drug targets a specific vomiting mechanism.

Info all on one thread now :-)
 
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killing me softly

killing me softly

don't wake me, i plan on sleeping in
Dec 28, 2018
171
Suicide/Toxification/Antiemetic regimen - Wikibooks, open books for an open world
The human body employs several distinct mechanisms to trigger vomiting in response to different stimuli. It follows that there is no universal antiemetic that would prevent vomiting irrespective of the cause; indeed, each particular antiemetic drug targets a specific vomiting mechanism.

Info all on one thread now :-)
almost...but you forgot to post a link about the proper dosage and administration of toast.
 
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color_me_gone

color_me_gone

Sun is rising
Dec 27, 2018
970
no universal antiemetic that would prevent vomiting
antiemetics help, but no guarantee, that is why drugs are unreliable, unless very powerful, like N
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
Suicide/Toxification/Antiemetic regimen - Wikibooks, open books for an open world
The human body employs several distinct mechanisms to trigger vomiting in response to different stimuli. It follows that there is no universal antiemetic that would prevent vomiting irrespective of the cause; indeed, each particular antiemetic drug targets a specific vomiting mechanism.

Info all on one thread now :-)

Thank you @Passingby you are a star :-)
You know I can barely remember what I had for breakfast - whether it was toast or chocolate so it's impossible for me to find something I was reading :-)
 
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A

Arak

Enlightened
Sep 21, 2018
1,176
I did try quetiapine once for insomnia. At low doses (for sleep), it didn't work. It did not or barely sedate. At low doses it's mostly an antihistamine.

More than once sources discusses tapering off benzodiazepines prior tot he attempt and resetting tolerance.
'You should really try 5ml to test the effect on yourself. It will give you an indication of its potentcy'I 'm sure it will have an effect.

@Passingby ,

'He should test the Phenytoin as well, I have :-) no ill effects .' I'm sorry, what do you mean ? It's supposed to kill you or not - not something in between.

@therhydler ,

'But is there an actual risk of surviving with brain/organ damage? Isn't it just a risk of entering a coma before you die? I don't mind being in a coma as long as im dead at the end and don't regain consciousness' That's basically my point. As an example, https://en.wikibooks.org/wiki/Suicide/Toxification/Pentobarbital

'The prolonged use of barbiturates leads to tolerance. Also, cross-tolerance between barbiturates and benzodiazepines can be presented, since both drugs act through the GABA receptors. Hence, it is suggested that a period of 3–4 weeks of withdrawal can reverse the tolerance and this process is indeed needed for having one's attempt be a reliable one. As with all intoxication procedures, it is recommended that all consumption of medications that do not affect judgement be stopped some time in advance to drug ingestion, as well as consumption of alcohol and narcotics. Anti-psychotics have been mentioned as one confounding factor in failed or prolonged attempts, according to The Peaceful Pill Handbook.'

'is indeed needed' I'm not quite sure about that. I checked the Dutch protocol, and they have a doc standing by to administer sodium pentothal and more. The Dutch source also mentions that achieving peak plasma values (related to absorption) is crucial.Obviosuly the numbers in the wiki above are promising, but one has to look at context. Not that many elderly will have been seriously messed up in The Netherlands with sedatives, and Dignitas has its own protocol. The 'sample group' matters.

Also, per the wiki '
A pentobarbital overdose is an amount taken in excess of that which is medically recommended. Two to ten grams can cause death. CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may show paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.

In extreme overdose, all electrical activity in the brain may cease, in which case a "flat" EEG normally equated with clinical death cannot be accepted. This effect is fully reversible unless hypoxic damage occurs. Consideration should be given to the possibility of barbiturate intoxication even in situations that appear to involve trauma.

Complications such as pneumonia, pulmonary edema, cardiac arrhythmias, congestive heart failure, and renal failure may occur. Uremia may increase CNS sensitivity to barbiturates. Differential diagnosis should include hypoglycemia, head trauma, cerebrovascular accidents, convulsive states, and diabetic coma. '

I'm not sure about the long comatose phase. What happens when that has been going on ? Caused by incomplete hypoxia ? Can you survive ?

The member who had just left this forum had studied alcoholism and Nembutal, so I cannot ask her about her sources. The phrase in the PPEH that alcoholism causes an enzyme related problem that interferes with the N does not seem plausible. A chronic effect on the receptors seems more likely. It's typical for doctors to attribute positive attributes to the drugs they prescribe.

Per the PPEH: 'It is presumed the induction of liver enzymes by these drugs causes some degradation of the Nembutal before it reaches the brain.' I do not see how that makes sense. It is absorbed into the bloodstream and enters the brain.

Doctors know how to make pentobarbital work. There is help, the odds will be in one's favor.

What is in favor of using pentobarbital is that I actually have it, 13 gr. I just don't want to live (handicapped) to tell the tale. I'm pretty much looking for anything to 'add' to improve the odds. Surely, it would knock me out.
 
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A

Arak

Enlightened
Sep 21, 2018
1,176
@Morpheus , you probably mean well but I do not like doing this on 'faith'.
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
@Arak obviously I do not wish to pry, so please don't answer if it's uncomfortable. Do you think your CNS is irreparably damaged or is it more a case that you would need to be without benzodiazepines for a period of 4-6 weeks and that would be impossible or impractical for you.
 
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killing me softly

killing me softly

don't wake me, i plan on sleeping in
Dec 28, 2018
171
Per the PPEH: 'It is presumed the induction of liver enzymes by these drugs causes some degradation of the Nembutal before it reaches the brain.' I do not see how that makes sense. It is absorbed into the bloodstream and enters the brain.
actually, blood never makes a direct path from the digestive system to the brain. the body's metabolic system is set up so that anything ingested is absorbed by the intestine into the blood stream. the blood flows to the liver which serves as a sort of filter or processing station. the 'good' stuff gets sent on to the rest of the body while the 'not so good' stuff is sent on it's way to the excretory system. this is obviously a really simplified way of looking at it.
 
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Letmego. Please

Letmego. Please

Wizard
Nov 18, 2018
619
Per the PPEH: 'It is presumed the induction of liver enzymes by these drugs causes some degradation of the Nembutal before it reaches the brain.' I do not see how that makes sense. It is absorbed into the bloodstream and enters the brain.

It's called first past metabolism. In essence most drugs are processed by specific liver enzymes & that can either work with you or against you by finding another drug that locks on to the specific enzyme that would process Pento, thus blocking its access to being metabolised on its first pass through the liver will increase toxicity.

It gets a bit wordy but this explains it well
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2044.2005.04462.x

P.s Sorry if its already here elsewhere.
 
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Deleted member 4993

Guest
Bioavailability - Wikipedia
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.


Well worth reading the highlighted > First - pass metabolism
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
@Arak just looking in the Pets Photos Megathread made me wonder whether you had a veterinarian friend you would be able to discuss your anxieties with?
 
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A

Arak

Enlightened
Sep 21, 2018
1,176
@JustAboutDone,
At the best it is seriously impaired, and there is no way to get it back anything close to 'normal' in few weeks.
There is no 'tapering off, and resetting your tolerance within weeks'. Not a lack of willpower. Hypothetical scenarios would be very, very long term. Not just a matter of a daily dose of one or two sleeping pills ...

I have never taken antipsychotics but appearently for some reason they can upset the effect of the pentobarbital. Not sure why.

@killing me softly ,

You may or may not have a point. I did not think that the liver functions as anything that is even close to a 'complete' and immediate filter for pentobarbital and other drugs, filtering out all relevant substances at once. If that were the case, it would exlain why chronic alcohol use would make Nembutal so ineffective since that theory of induction of enzymes in the liver could indeed work that way.

But that's a good point. To what extent does the liver act as a filter for the Nembutal ? It was my impression that it was limited at best, and that it would gradually break down drugs and other substances in the bloodstream over time, not instantly. That's a question for someone with a medical background. I just looked around on the internet for a few moments, I coudl not find a clear answer to this question. I'll check again later.

@JustAboutDone , nope and if you mean A I destroyed the emails as requested.

I did read a few credible stories on the internet, including a man who has ingested 12 or 13 gr of N. He was found by his wife 7 or 8 hours later and ultimately 'saved' in a hospital. Makes you wonder about the 'delayed comatose phase'.
 
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JustAboutDone

Illuminated
Jan 1, 2019
3,532
Given the research you have been doing, and the issues you have with the benzodiazepines, have you thought about looking at the 'Amitriptyline Cocktail' as an alternative?

However, I don't think humans are comparable species. We are not bred as identical lab rats therefore if one person doesn't die from, say, 20g of N, it can't really be used as a model. Do you think your anxiety about death is making you over concerned?
 
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killing me softly

killing me softly

don't wake me, i plan on sleeping in
Dec 28, 2018
171
@killing me softly ,

I did not think that the liver functions as anything that is even close to a 'complete' and immediate filter for pentobarbital and other drugs, filtering out all relevant substances at once.

To what extent does the liver act as a filter for the Nembutal ? It was my impression that it was limited at best, and that it would gradually break down drugs and other substances in the bloodstream over time, not instantly.

what you're getting into here is toxicity. you're right, the liver is not capable of fully processing and filtering pentobarbital when taken in such a large dose, which is why it is potentially fatal. but to the original point, you questioned the pph claim that there may be some degradation or loss from liver processing. given the body's mechanism of metabolism this is not an unreasonable assertion.

you seem to be in search of the perfect, no-fail method. i would think by now you would understand there isn't one. every single method comes with certain draw backs, risks, unpleasantness. N is no different.
 
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A

Arak

Enlightened
Sep 21, 2018
1,176
@JustAboutDone , I'm looking at alternative poisons (even thought of ricin - dreadful, can take 6 weeks, irreversible, but probably impossible to obtain). Amitryptiline https://en.wikibooks.org/wiki/Suicide/Amitriptyline_cocktail
works this way: '
Tricyclic antidepressants (TCAs) exert their lethality mainly since they are sodium channel blockers.[1]
. ' I'm sure there is the potential for lethality, but certainty ?
 
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Arak

Enlightened
Sep 21, 2018
1,176
@killing me softly , actually if the liver were a near 100 % filter that would give credibility to the claim that alcoholism can affect liver enzymes which would make a lethal N dose much harder. That was what I was getting at. Alcohol versus prescription drugs.

Doctors attitudes 'it's safe if we prescribe'.
 
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