N metabolism question

[Jengator]

I had a question about liver metabolism and N.

If my medical condition is such that my liver is in really bad shape and doesn't metabolize drugs well, could N as a method of CTB backfire?

Thank you

 

[Brick In The Wall]

This is a tough one, I'd imagine your body would metabolize it in much the same way it would any other drug. But I'm definitely not a professional on this and I'm purely speculating here. Hopefully my comment will bump this thread up and it'll catch the eye of someone more knowledgeable on this.

 

[chris8000]

That's interesting, when a drug passes through the intestines it first goes to the liver for potential metabolism before systemic circulation.

First pass effect - Wikipedia

en.wikipedia.org

As I understand it, N does not require metabolism to work, but it is metabolised by the liver before excretion.

You can see there is a paper about N in patient's with liver disease from the 50s here, and it says there is no evidence the individuals were more sensitive to N who had liver disease and so impaired inactivation of N:

Sessions, John T., et al. "The effect of barbiturates in patients with liver disease." The Journal of clinical investigation 33.8 (1954): 1116-1127.

I'd guess it would be the other way round, people with impaired livers would be more sensitive to N and not less (although this paper says there is no effect).

You might want to speak with some one who is a medical doctor, although phrasing the question might be a bit tricky, haha.

 

[chrijo]

You don't need a pento-metabolism for suicidal intent. If you have trouble with different drugs, it is because of slowed/stopped degradation or lack of important metabolites that are biotransformed by the liver.

Pentobarbital = active metabolite and does not need to be biotransformed.

 

[Jengator]

You don't need a pento-metabolism for suicidal intent. If you have trouble with different drugs, it is because of slowed/stopped degradation or lack of important metabolites that are biotransformed by the liver.

Pentobarbital = active metabolite and does not need to be biotransformed.

I see. So metabolism is for the purpose of excretion and not for the drug to work? Basically...

 

[calendulo]

It is known that all the process will be slower if the liver is not in a decent condition, of course I mean if the target is to die.
A health liver is a sure success.

 

[heavyglow]

Actually you die faster because your Body is Not Able to get rid of it. i am a doctor.

 

[Jengator]

Thank you Doc

 

[calendulo]

Actually you die faster because your Body is Not Able to get rid of it. i am a doctor.

Ah, what I have read is opposite to that, specially about alcoholic problem persons.
Althought right now I have doubts about time to die or more pain......

 

[heavyglow]

When you inject it it bypasses the liver anyway, and it sure works. You just need an intact gastrointestinal system for absorption

 

[Jengator]

I have oral liquid N
My liver's enzymes and P450 metabolism pathways have been damaged by heavy metals and medication (Cipro)