Help Is Domstal (Domperidone ) good enough for SN?

[Currycel1234]

Can you use it just like Metachlorpramide, or does it need another regimen?

 

[TimeToBiteTheDust]

Can you use it just like Metachlorpramide, or does it need another regimen?

Read Stan's guide. There you can find all the alternatives to meto.

 

[dreamsofdestruction]

Read Stan's guide. There you can find all the alternatives to meto.

In fact, he lists Domperidone first and Metoclopramide in the second place. Is there a significant difference between the two anyway?

 

[jake3d]

TL;DR version: Domperidone + Ondansetron (Zofran) = meto. Without the side effects too.

 

[jgm63]

Domperidone is apparently not compatible with H2 blockers such as Tagamet / Zantac. The general opinion seems to be to stick with a basic antacid if using domperidone, eg Rennie, milk of magnesia, etc. Note that antacid is not considered to be essential, so it could be omitted.

Some dosage notes are here :

Spoiler: post-509925

https://sanctioned-suicide.net/threads/n-protocol-regime-regimen-notes.27092/post-509925

If using the 48 hour regime for domperidone, it might be a good idea to go with the "extra" 3x dose at the final interval, as Stan's guide states, since I've heard that domperidone may not "accumulate" as well as metoclopramide.

However, I think the main advantage of the 48 hour regime over the stat is reduced EPS risk, but since domperidone has a very low EPS risk then I'm sure there's any real point of doing the 48 hour regime, and it may just be easier to go with the stat method.... (but if someone has some solid evidence to correct me on this, I'd be happy to learn more).

Although I wrote 20mg stat for domperidone in the above notes (based on peaceful pill handbook), I've seen threads with people using higher amounts, so you could probably just go with 30mg.

So my view would be perhaps just go with the stat regime, and use the same dose as you would for meto, and just observe the antacid point made above....

However, the above are purely my thoughts based on the limited research I've done. I obviously can't give any guarantees as to how correct they are, and I'm no expert.

 

[dreamsofdestruction]

TL;DR version: Domperidone + Ondansetron (Zofran) = meto. Without the side effects too.

Why is that?

 

[Quarky00]

Why is that?

Because meto cross blood-brain-barrier. Side effects caused in brain, with 5HT3 receptors.

Ondansetron targets peripheral 5HT3 receptors, it does not get into the brain, less side effects.

Domperidone (Dopamine, no BBB) + Ondansetron (5HT3, no BBB) = meto (Dopamine+5HT3 , BBB/EPS)

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Domperidone is apparently not compatible with H2 blockers such as Tagamet / Zantac

Why is that?

#closure

 

[Busdriver]

I found sort of an explanation.
But then again, acid reducers are the least important part of SN.

Sorry for bumping old thread