There are plenty of opportunities for it - covid or another virus that we unleash, the vaccine backfiring and making people ill / infertile, the extinction crisis, global warming (if it really is a big problem - I suppose it is because it makes the extinction problem worse), food shortages, civil unrest disrupting supplies of food and etc, massive cyber attack knocking out banking system, power system, comms, etc (like the recent solar winds exploit), etc.
And war of course which could quickly escalate to full on nuclear.
I think in the end our downfall will be down to us rather than an asteroid - even covid is our fault for invading territories where we shouldn't be.