Long story short I can't get antimetics so I decided to supplement it with DMSO. How much pain will I feel if I drink 100ml of DMSO mixed with 20g of Sodium Nitrite? What else should I know?
Did you also try to get domperidone or any dopamine blocker class of antiemetic?
I didn't research things well yet. But I had already seen a few things up to this day.
- I don't know if DMSO has an antiemetic property. People usually take it because it increases the absorption rate of sodium nitrit. There is still risk of vomiting.
I vomited. I don't know how much I have that in my stomach now, but I think that much of them has been puked.
I feel similar to partial hanging. Vision want to turn black, but it don't.
I hear some noise..
Dimethyl sulfoxide (DMSO) is widely used as a solvent for other drugs, i.e., for the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) and the V1a receptor-antagonist SR49059, to reduce brain edema. We studied the effect of DMSO on blood-brain barrier (BBB) integrity following...
Dimethyl sulfoxide (DMSO) is a solvent that is routinely used as a cryopreservative in allogous bone marrow and organ transplantion. We exposed C57Bl/6 mice of varying postnatal ages (P0–P30) to DMSO in order to study whether DMSO could produce ...
www.ncbi.nlm.nih.gov
You probably have access to 5ht3 antagonists. They are also antiemetics as well despite they aren't as strong as dopamine blockers.
.
Most over-the-counter (OTC) antiemetics are usually used for travel sickness. Examples of such a drug is dimenhydrinate (Dramamine, Gravol). They work through the hisaminic receptors and the cholinergic receptors, thus they would not be suitable for drug-induced vomiting, which is triggered through other neurotransmitters.
An other class of antiemetics that would only be slightly efficient for drug-induced vomiting are those which are used for post-surgery emesis and chemotherapy-induced emesis. Those are the class of drugs which inhibit the 5-HT receptors (serotonin blockers and drugs which work through the vagus nerve). To some extent, those drugs can lower the drug-induced vomiting, but it would not be the antiemetic of choice for this purpose, since serotonine is not the main neurotransmitter for triggering the brain's vomiting centre when a drug overdose is ingested. Dopamine is the main neurotransmitter for that.
The third class of antiemetics is the one that would be suitable for our purpose. Those are the class of dopamine blockers, and therefore they would work best for inhibiting drug-induced vomiting.
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.