It's when someone intentionally loads a syringe with a lethal amount of drugs. Addicts often get help from someone to find a vein and shoot them up. Sometimes an opportunistic junkie will administer a hot shot to take a person out so it looks like an OD either to settle a grievance or collect. A person could give themselves a hot shot in order to make their own suicide look like an OD to protect their posthumous reputation and spare their loved one's from the added shame of a suicide.
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