Hi can anyone with knowledge about medications tell me about what dosage to take of Tramadol for depression and anxiety?

[HermitLonerGuy]

so after doing research and findin out the pain medication Tramadol is a very good anti depressant i started taking it and feel a better mood and almost normal.
now i want to take a safe dose , is it fine taking 2 tramadols daily? 50mg.

With no damage?

Its an opioid and also an SNRI.
from wiki:

"Tramadol is converted in the liver to O-desmethyltramadol (desmetramadol), an opioid with a stronger affinity to the μ-opioid receptor.[3]​[14]​ Tramadol is also a serotonin–norepinephrine reuptake inhibitor (SNRI).[3]​[15​ "

Its also similar to the anti depression medication Venlafaxine.

"The analgesic tramadol has many characteristics in common with the antidepressant venlafaxine. The drugs are structurally similar, share both serotonergic and noradrenergic properties, and undergo a similar metabolic fate. "

Similar effects of tramadol and venlafaxine in major depressive disorder - PubMed

The analgesic tramadol has many characteristics in common with the antidepressant venlafaxine. The drugs are structurally similar, share both serotonergic and noradrenergic properties, and undergo a similar metabolic fate. In this study, a patient, who developed significant depression following...

pubmed.ncbi.nlm.nih.gov

Please advise.

 

[MentalStefan]

Using tramadol is not a safe way to cope with depression and anxiety. Tramadol works similarly to antidepressants however psychiatrists say that you should take venlafaxine instead of tramadol to treat depression and anxiety. Tramadol is an opioid, which means It is highly addictive and it might damage your digestive system - may cause severe constipation, extreme bloating, bad gas and moderate stomach ache. As an opioid user I can confirm that opioids cause a lot of stomach problems.

 

[HermitLonerGuy]

Using tramadol is not a safe way to cope with depression and anxiety. Tramadol works similarly to antidepressants however psychiatrists say that you should take venlafaxine instead of tramadol to treat depression and anxiety. Tramadol is an opioid, which means It is highly addictive and it might damage your digestive system - may cause severe constipation, extreme bloating, bad gas and moderate stomach ache. As an opioid user I can confirm that opioids cause a lot of stomach problems.

Low-Dose Tramadol as an Off-Label Antidepressant: A Data Mining Analysis from the Patients’ Perspective

Objectives: The purpose of this analysis was to assess, from the patients’ perspective, the effectiveness and relative safety of tramadol as an off-label antidepressant and to determine if patients’ views and experiences are consistent ...

www.ncbi.nlm.nih.gov

Is tramadol better than antidepressant?


When compared to 34 other antidepressants in the database titled Drugs Used to treat Depression (https://www.drugs.com/condition/depression.html), for which there were ≥100 individual reviews for each drug, tramadol was rated as being the most effective (effectiveness rating = 9.1/10).

antidepressant​	number of reviews​	effectiveness rating​
1​	tramadol (off-label)​	139​	9.1 ​

42​

venlafaxine​

887​

6.1​