Have tried ketamine in all dose ranges, except coma amounts. Sourced "underground".
It does work temporarily for depression. It's almost eerie how well it can work.
Feels like you were in a horrible traffic accident and got your bones powdered by a steamroller, then you wake up the next day feeling fine, only for it implode and reverse after a few days.
Caveat Emptor: The addictive potential is very real. Especially at low doses.
High doses where you cant remember if you are alive or dead or what existence even means is a bizarre experience I don't care to repeat.
It does have utility, in my opinion.
In the afterglow where the depression is temporarily lifted, a differential diagnosis can be attempted, and plans can be made with a patient.
Some also report complete resolution of depression and/or anxiety simply after one big ass dose.
There are some marvelous podcasts about it on
https://www.plantmedicine.org/